Studies on the Syntheses and Properties of Poly(ester anhydride)s for DDS

Abstract

Abstract: 4,4′-(Adipyldioxyethyoxy)dibenzoic acid(1a), 4,4′-(sebacoyldioxyethyoxy)dibenzoic acid(1b) and 4,4′-(benzoyldioxyethyoxy)dibenzoic acid(1c) were synthesized and converted into mixed anhydrides by the reaction with acetic anhydride. Poly(ester-anhydride)s 2a, 2b and 2c were yielded by subsequent melt polycondensation. Their chemical structures were confirmed by ¹H NMR, IR, UV and elemental analysis. In vitro degradation of poly(ester-anhydride)s in phosphate buffer solution at 37 ℃ was determined. Drug release profile of Ciprofloxacin was also studied.

Key words: Poly(ester-anhydride), Drug controlled release, Ciprofloxacin

CLC Number:

O631

TrendMD:

FU Jie, ZHUO Ren-Xi, FAN Chang-Lie . Studies on the Syntheses and Properties of Poly(ester anhydride)s for DDS[J]. Chem. J. Chinese Universities, 1998, 19(5): 813.

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Studies on the Syntheses and Properties of Poly(ester anhydride)s for DDS

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