Novel Synthesis of Diethyl(1-naphthylmethyl)-tetrahydrofurfurylmalonate

Abstract

Abstract: An important precursor of nafronyl oxalate, diethyl(1-naphthylmethyl)-tetrahy-drofurfurylmalonate(Ⅴ) has been synthesised by using diethyl malonate(Ⅰ), furfural(Ⅱ) and 1-(chloromethyl) naphthalene as starting materials. Anew catalyst system, NaH/DMF, is applied to the alkylation of naphthylmethyl chloride and diethyl tetrahydrofurfurylmalonate(Ⅳ) with satisfactory results. Compared with previous methods, it has a higher yield and shorter reaction time. Other alkylation catalysts are investigated as well.

Key words: Synthesis, Condensation, Catalytic hydrogenation, Alkylation

CLC Number:

O624

TrendMD:

ZHOU Zhi-Ming, CHEN Nan . Novel Synthesis of Diethyl(1-naphthylmethyl)-tetrahydrofurfurylmalonate[J]. Chem. J. Chinese Universities, 1998, 19(12): 1979.

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Novel Synthesis of Diethyl(1-naphthylmethyl)-tetrahydrofurfurylmalonate

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