Abstract: According to the hydrophilicity, flexibility, accessibility, charge distribution and β-turn in the secondary structure by the determination of the primary structure, six antigenic peptides of 26000 glutathione S-transferase, Sm26/2, of schistosoma mansoni have been predicted by using programs Goldkey and PC-Gene with the aid of computer. They were synthesized by using solid phase method. Two of them showed a good antigenicity by Dot ELISAmethod with anti schistosoma japonicum-immunoglobulin polyclonal antibody, anti Sj-IgG PcAb. One of them also showed good antigenicity with the anti-schistosoma surface membrane monoclonal antibody, A6McAb. They would be as candidate peptides of synthetic peptide vaccine against schistosomiasis.

Key words: Schistosoma mansoni, Glutathione S-transferase, Antigenic peptide, Peptide vaccine