Studies on the Reaction of 1-Benzoyl-1-methylthiomethanol with Thioureas and Arylamines

Abstract

Abstract: 1-Benzoyl-1-methylthiomethanol(2) can react with thiourea(3a) and arylthioureas( 3b_3i ) in the slightly acidic medium to afford 5-phenylimidazolidine-2-thione-4-one(4a) and 1-aryl-5-phenylimidazolidine-2-thione-4-ones(4b_4i). On the other hand, when compound 2 was refluxed with arylamines in the slightly alkaline medium, 2-arylamino-2-methylthioacetophenones(6a_6f) can be obtained. Their structures are confirmed by X-ray, IR, ¹H NMR, MSand elemental analysis.

Key words: 1-Benzoyl-1-methylthiomethanol, 1-Aryl-5-phenylimidazolidine-2-thione-4-one, 2-Arylamino-2-methylthioacetophenone

CLC Number:

O625

TrendMD:

ZOU Jian-Ping, LIU Xian-Jun, XU Yong, LU Zhong-E . Studies on the Reaction of 1-Benzoyl-1-methylthiomethanol with Thioureas and Arylamines[J]. Chem. J. Chinese Universities, 1998, 19(10): 1589.

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Studies on the Reaction of 1-Benzoyl-1-methylthiomethanol with Thioureas and Arylamines

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