Studies on Three-dimensional Quantitative Structure-activity Relationship of PDE Inhibitory Activity of Imidazopyridines

Abstract

Abstract: In recent years there has been a resurgence of interest in inhibitors of cyclic nucleotide phosphodiesterases (PDE) and enzymes responsible for the intracelluar hydrolysis of the second messenger cAMP and cGMP. In this study, a series of 2-subsituted phenyllimidazo[4, 5-b]pyridines have been made to investigate 3D-QSAR of PDE activity using CoMFA. CoMFA resulted in a quantitative description of the major steric and electrostatic field effects, and gave significant new insights to factors governing PDE inhibition activity. The model was used to predict the PDE inhibition activity of imidazopyridines with satisfactory results.

Key words: 3D-QSAR, CoMFA, Imidazopyridines

CLC Number:

O631

TrendMD:

LI Hua, XU Lu, SU Qiang . Studies on Three-dimensional Quantitative Structure-activity Relationship of PDE Inhibitory Activity of Imidazopyridines[J]. Chem. J. Chinese Universities, 1998, 19(1): 43.

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Studies on Three-dimensional Quantitative Structure-activity Relationship of PDE Inhibitory Activity of Imidazopyridines

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