Studies on Carbohydrates (XXV)──Synthesis of Disaccharide Units of Serratia marcescens O4 Antigen Oligosaccharide

Abstract

Abstract: Ablocked disaccharide portion of the biological repeat unit, [→4) α-D-Glcp (1→3)-α-L-Rhap (AcO→2) (1→] of the Serratia marcescens O4 oligosaccharide wasprepared by using 1-O-trlfluoroacetoxy, trlchloroacetoxy or trichloroacetimido as leaving groupof sugar in the presence of Lewis acid. The reaction conditions were very mild, and theyields were also good. Trlfluoroacetoxy and trlchloroacetoxy are good leaving groups and af-ford the products in a high stereoselectivity. All compounds were confirmed by IR, MS, Hand ¹³C NMRspectral methods.

Key words: Serratia marcescens, O-antigen, Oligosaccharide, Synthesis

CLC Number:

O629.12

TrendMD:

ZHANG Ke-Qin, LI Shu-Chun, MAO Jian-Min, CHEN Hong-Ming, CAI Meng-Shen. Studies on Carbohydrates (XXV)──Synthesis of Disaccharide Units of Serratia marcescens O4 Antigen Oligosaccharide[J]. Chem. J. Chinese Universities, 1997, 18(9): 1469.

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Studies on Carbohydrates (XXV)──Synthesis of Disaccharide Units of Serratia marcescens O4 Antigen Oligosaccharide

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