Synthesis of Poly(ether-ester) with PEG Selectively Grafted onto Different Segments and Its Antithrombogenicity

Abstract

Abstract: α-Methyl-ω-(2, 3-epoxy)propyl poly (ethylene glycol) (Ⅱ) was hydrolyzed to a glycol (Ⅲ) with a pendent poly (ethylene glycol) (PEG) chaln.Poly (ether-ester) (PEEs)with PEGgrafted ont0 the hard segments (H-PEEs) was synthesized by reacting the glycol (Ⅲ), terephthaloyl chloride and poly (butylene glycol) The macromer (Ⅱ) cationically copolymerized with tetrahydrofuran to give a copolyether (Ⅳ) grafted with PEG.Using copolyether(Ⅳ) having an average 1.25 grafts per molecule, the S-PEEs with PEGgrafted onto soft segments was synthesized.The recalcification time for SuPEEs remalned almost unchanged in comparing with ungrafted PEEs, while that for HuPEEs increased by about 100%, even though the hydrophlcillties both of S-PEEs and H-EEs were ralsed slgniflcantly.

Key words: poly (ether-ester), Macromer, Ring-opening copolymerization, Graft copolymer, Antithrombogenicity

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LIU Chun-Qi, RUAN Ji-Hong, ZHANG Hong-Zhi, FENG Xin-De. Synthesis of Poly(ether-ester) with PEG Selectively Grafted onto Different Segments and Its Antithrombogenicity[J]. Chem. J. Chinese Universities, 1997, 18(3): 477.

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Synthesis of Poly(ether-ester) with PEG Selectively Grafted onto Different Segments and Its Antithrombogenicity

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