Synthesis of an Receptor Containing Chiral Bicyclic Guanidine for Amino Acids

Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (11): 1800.

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Synthesis of an Receptor Containing Chiral Bicyclic Guanidine for Amino Acids

HE Wei-Jiang¹, LU Guo-Yuan¹, HU Hong-Wen¹, JavierdeMendoza², PilarPrados²

1. Department of Chemistry, Nanjing University, Nanjing 210093;
2. Departamento de Quimica, Universidad Antonoma de Madrid, Madrid 28049

Received:1996-10-07 Online:1997-11-24 Published:1997-11-24

Abstract

Abstract: An artificial receptor 1 for aromatic amino acids was prepared from a chiralbicycllc guanidine salt 2 by means of a new procedures.The deprotecting silylethers 2 and 4were selectively achieved in solutions of CH₃COOH-THF-H₂Oand HF-Pyridine respectively.Thus the receptor 1 was readily obtained upon reaction of the monosubstituted naphthoylester 5 with bromoacetic acid and then mono-azacrown ether.The total yield in five steps was40.5%.

Key words: Receptor, Amino acid, Molecular recognition, Synthesis

CLC Number:

O626

TrendMD:

HE Wei-Jiang, LU Guo-Yuan, HU Hong-Wen, JavierdeMendoza, PilarPrados. Synthesis of an Receptor Containing Chiral Bicyclic Guanidine for Amino Acids[J]. Chem. J. Chinese Universities, 1997, 18(11): 1800.

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Synthesis of an Receptor Containing Chiral Bicyclic Guanidine for Amino Acids

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