Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (1): 64.

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Studies on the Mannich-type Reaction of p-Toluenesulfonylurea

DAI Qing, CHEN Ru-Yu   

  1. Institute of Elemento-Organic Chemistry and State's Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1996-01-05 Online:1997-01-24 Published:1997-01-24

Abstract: The Mannich-type reaction invoIving p-toluenesulfonylurea with aromatic aldehy-des and dialkyl phosphite was studied and the reactivities of various kinds of amides were compared by a competing reaction.Anew type of a-amino phosphonic acid derivatives were synthesized and the structures of the products were confirmed by 1HNMRand elemental analyses.The bioassay shows that some of them possess good anti-TMV(Tobacco Mosaic Virus) activity.

Key words: p-Toluenesulfonylurea, Mannich-type reaction, α-Amino phosphonic acid, Biological activity, Anti-TMV

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