CJCU

Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (5): 815.

• Articles • Previous Articles     Next Articles

The Study on a Novel Anticoagulative Material

YING Xi-Zhang1, WANG Bei-Bei1, YAO Shi-Kai1, ZHU Jian-Guo1, ZHU Li-Hong2, SHAO Hui-Zhen2, MA Ting3, YAO Hong-Xi4   

  1. 1. Basic Medical College, Shanghai Second Medical University, Shanghai 200025;
    2. Shanghai Institute of Hematology, Ruijin Hospital;
    3. Department of Applied Chemistry, Shanghai Jiao-Tong University;
    4. Physicochemical Laboratory Center, Shanghai Jiao-Tong University
  • Received:1995-05-10 Online:1996-05-24 Published:1996-05-24

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Abstract: The heparin has been grafted directly on the surface of polyurethane with the help of hypothermia plasma treatment.The smooth polyurethane-heparin graft copolymer is deeped in the inside tube wall.By dotting time (CT)test fresh human blood is injected to the polyurethane-heparin graft tube,after 5 days and nights there isn' t any thrombin the inside tube wall.By kaolin partial thomboplastin time (KPTT), prothrombin time(PT)and thrombin time (TT)tests to these polyurethane-heparin graft tubes, the results are that,this novel graft tube has anticoagulation visibly and there isn't falling free heparin from the tube wall, In infrared spectrum peaks 1165 cm-1 and 1339 cm-1 are symmetric and antisymmetric stretch vibrations of SO2 group in new covalent bond N—SO2 or O-SO2.

Key words: Hypothermia plasma, Polyurethane-heparin graft copolymer, Anticoagulation

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