Abstract: Six antigenic peptides of the 26KDa Glutathione S-transferase of schistosoma mansoni have been predicted according to its hydrophilicity, flexibility,accessibility,chargedistribution and β-turn in the secondary structure by the determination of its primary structure with the aid of computer and synthesized by using solid phase method.Two of them showed a good antigenicity by Dot-ELISAmethod with anti-schistosoma japonicum-immunoglobulin polyclonal antihody,anti-Sj-IgG PcAb and one of them also showed a good antigenicity with the anti-schistosoma surface membrane monoclonal antibody,A6McAb.

Key words: Schistosoma mansoni, Glutathione S-transferase, Antigenic peptide, Peptide vaccine