Abstract: The synthesis of N-phenylsulfonyl phosphordaimides was reported.The effects of the structures of the compounds on the insect glutamate potentials were investigated by using electrophysiological intracellular microelectrode recording technique. The results showed that all of the compounds could block the neuromuscular junctional excitation potentials (EJP),but the blocking time had a great difference. The blocking action could be divided into three types:(1)EJP were blocked progressively;(2)EJP were blocked after a short exciting period;(3)EJP were blocked rapidly. The results of the bioassay showed that the compounds which possessed the second action mechanism had the best killing effect.

Key words: Phenylsulfonyl phosphordiamide ester, Glutamate receptor tunnel, Blocking time, Blocking process