Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (6): 915.

• Articles • Previous Articles     Next Articles

Synthesis of Ribozyme Substrates Containing Chiral Methylphosphonate at Cleavage Site

ZHOU Ying-Zi, WANG Lai-Xin, ZHANG Li-He   

  1. State Key Laboratory of Natural and Biominietic Medicine, Beijing Medical University, Beijing, 100083
  • Received:1995-01-03 Revised:1995-03-20 Online:1995-06-24 Published:1995-06-24

Abstract: Two stereoisomers of dicytidylyl methylphosphonate 10 and 11 were synthesized and used as a block for the synthesis of ribozyme substrates containing chiral center at the cleavage site.

Key words: Ribozyme, Dicytidylyl methylphosphonate, Stereochemistry, Chiral substrate

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