Abstract: Eight of the title compounds, N-aryl-isopropyl-carbamoyl methyl phosphonamidate(Ⅰ)(i-prNHC(O)P(O)(OMe)NHAr, Ar=substituted phenyl, substituted pyridyl),were synthesized by reacting the phosphonyl chloride with arylamine under a mild condition in order to study the method of the synthesis of this kind of compounds and look for efficient antiviral drugs and pesticides. The preliminary bioassay showed that the title compounds had little bioactivity. The structure of the compounds had been studied and ¹HNMR showed that there were two kinds of inter-molecular hydrogen bondings in the compounds.

Key words: Phsophonamidate, Carbamoylphosphonate, Hydrogen bonding