Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (6): 932.

• Articles • Previous Articles     Next Articles

Synthesis and Drug Release Property of Biodegradable Polyphosphate Esters

LUO Yi, ZHUO Ren-Xi, FAN Chang-Lie   

  1. Department of Chemistry, Wuhan University, Wuhan, 430072
  • Received:1993-05-31 Revised:1993-11-24 Online:1994-06-24 Published:1994-06-24

Abstract: Polyphosphate esters were synthesized by the catalytic solution polycondensation of biphenols with dichlorophosphoric acid ethyl ester, dichlorophosphonoformic acid ethyl ester or dichlorophosphonoacetic acid ethyl ester, respectively.The polypliosphate esters obtained were characterized by IR, 1H NMRand elementary analysis.The in vitro drug release of 5-fluorouracil was studied in pH7.4 phosphate buffer solution at 37℃.

Key words: Polyphosphate ester, 5-Fluorouracil, Drug-controlled release

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