Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (4): 466.

• Articles • Previous Articles     Next Articles

Polymerizational Kinetics of Metallothionein

ZHANG Bao-Lin1, REN Hong-Wei2, WANG Wen-Qing2   

  1. 1. Coordination Chemistry State Key Laboratory, Nanjing University, Nanjing, 210008;
    2. Technical Physics Department of Peking University, Beijing
  • Received:1992-11-12 Revised:1992-12-28 Online:1993-04-24 Published:1993-04-24

Abstract: Chromatographic separation of the aqueous solutions of rabbit hepatic (Cd,Zn)7MTin50 mmol/Lsodium phosphate (pH 7.40) after storing for various time was performed on HPLCin an attempt to investigate the thermodynamic stability of the Metallothionein (MT) solution.It was found that MTcould polymerize slowly by itself.Assuming the polymerization only occurs from monomer to dimer, an apparent bimolecular rate constant of the order of 10-3(mol/L)-1·/day-1 at 4℃ was obtained.The results also clearly reveal that the isoform MT-2 can polymerize more easily than MT-1.

Key words: Metallothionein, Polymerization, Kinetics

TrendMD: