Synthesis and Characterization of Thermoresponsive Polypeptide/polypeptoid Block Copolymers

doi:10.7503/cjcu20200651

Abstract

Abstract:

Thermoresponsive polymer refers to a type of polymer that can respond to external temperature and the molecular structure exhibit reversible or irreversible changes， that show great potential for both fundamental research and applications. In this work， both polypeptide and polypeptoid are involved to construct a new type of thermoresponsive block copolymers， which combine the structural advantages for tunable properties. We used n-hexylamine as an initiator and synthesized a series of thermoresponsitive diblock copolymer oligo（ethylene glycol） modified poly（γ-propargyl-L-glutamate）-block-poly（N-octylglycine）［（PPLG-g-EG₃）-b-PNOG］ with narrow molecular mass distribution by ring-opening polymerization and post-modification strategy. The crystallization behavior of the polymers was studied by differential scanning calorimetry. Circular dichroism（CD） spectrum was used to investigate the secondary structure of the polymer， and its self-assembly behavior in aqueous solution was further investigated. The results show that the thermoresponsitive polymers adopt α-helix at room temperature. As the temperature increases， the fraction of α-helix decreases. Additionally， the obtained polymers exhibit cylindrical nanostructure in aqueous solution.

Key words: Polypeptoid, Ring-opening polymerization, Temperature response, Secondary structure, Self- assembly (Ed.: W, K, S)

CLC Number:

O631.3

TrendMD:

LI Rongye, NI Yunxia, LIU Dandan, LI Zhi, CHENG Yuxin, XIA Mingxin, FU Xiaohui. Synthesis and Characterization of Thermoresponsive Polypeptide/polypeptoid Block Copolymers[J]. Chem. J. Chinese Universities, 2021, 42(3): 850.

Figures/Tables 7

References 24

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Sample	Feed ratio(PLG/NOG)^a	m/n^b	10^-3M_n^c	10^-3M_n^d	PDI^d
(PPLG?g?EG₃)₄₀?b?PNOG₁₇	40∶20	40∶17	20.5	11.2	1.20
(PPLG?g?EG₃)₅₈?b?PNOG₉	60∶10	58∶9	27.1	15.2	1.13
(PPLG?g?EG₃)₆₁?b?PNOG₁₆	60∶20	61∶16	29.6	21.0	1.21

Sample	Feed ratio(PLG/NOG)^a	m/n^b	10^-3M_n^c	10^-3M_n^d	PDI^d
(PPLG?g?EG₃)₄₀?b?PNOG₁₇	40∶20	40∶17	20.5	11.2	1.20
(PPLG?g?EG₃)₅₈?b?PNOG₉	60∶10	58∶9	27.1	15.2	1.13
(PPLG?g?EG₃)₆₁?b?PNOG₁₆	60∶20	61∶16	29.6	21.0	1.21

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