The Oxidation of Bilirubin in the Presence of Hydroquinone and Its Analytical Application

Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (2): 167.

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The Oxidation of Bilirubin in the Presence of Hydroquinone and Its Analytical Application

ZENG Bai-Zhao, ZHENG Yu-Xia, ZHOU Xing-Yao

Department of Chemtstry, Wuhan University, Wuham, 430072

Received:1992-01-29 Revised:1992-11-10 Online:1993-02-24 Published:1993-02-24

Abstract

Abstract: In basic medium, when hvdroquinone was present, bilirubin can be rapidly oxidized to a green product, the product that was confirmed to be biliverdin can produce a sensitive polarographic wave at about -0.82 V{vs.SCE).Therefore the reaction system was suggested to be used for the preparation of biliverdin and indirect determination of bilirubin.By using various electrochemical methods and spectrum techniques, the interaction mechanism of bilirubin with hvdroquinone was investigated, and it was confirmed to be a free radical reaction which was related to the dissolved oxy gen.In this paper, the influence of various factors on the reaction was also researched.

Key words: Bilirubin, Biliverdin, Hydroquinone, Free radical reaction

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ZENG Bai-Zhao, ZHENG Yu-Xia, ZHOU Xing-Yao. The Oxidation of Bilirubin in the Presence of Hydroquinone and Its Analytical Application[J]. Chem. J. Chinese Universities, 1993, 14(2): 167.

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The Oxidation of Bilirubin in the Presence of Hydroquinone and Its Analytical Application

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