Studies on the Acylaminothiosemicarbazides and the Related Heterocyclic Derivatives(ⅩⅩⅤ)——Synthesis of-1-(2,4-dichIorophenoxylacetyl)-4-aroylthiosemicarbazides and Studies on Its cyclization Behavior Under Basic Catalysis

Abstract

Abstract: In this paper, a series of new l-(2, 4-dichlorophenoxyacetyl)-4-aroylth-iosemicarbazides 3 were synthesized by the addition reaction of 2,4-dichlorophenoxyacetic acid hydrizide with aroyl isothiocyanate and the behavior of cyclization of compounds 3 in the presence of 2 mol/L KOHwere studied.The result shows that the reaction of compounds 3 in an alkaline medium gave 3-aryl-4H-l,2,4-triazoline-5-thione 4.The mechanism for the formation of compounds 4 was discussed.The structures of compounds prepared were characterized by elementary analysis, IRand MS.

Key words: Acylaminothiosemicarbazide, Heterocyclic, 1,2,4-triazoline-5-thione

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ZHANG Zi-yi, LIN Hai-xia . Studies on the Acylaminothiosemicarbazides and the Related Heterocyclic Derivatives(ⅩⅩⅤ)——Synthesis of-1-(2,4-dichIorophenoxylacetyl)-4-aroylthiosemicarbazides and Studies on Its cyclization Behavior Under Basic Catalysis[J]. Chem. J. Chinese Universities, 1992, 13(7): 936.

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Studies on the Acylaminothiosemicarbazides and the Related Heterocyclic Derivatives(ⅩⅩⅤ)——Synthesis of-1-(2,4-dichIorophenoxylacetyl)-4-aroylthiosemicarbazides and Studies on Its cyclization Behavior Under Basic Catalysis

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