Determination of Morphine in Urine of Drug Addicts by Gas Chromatography-Mass Spectrometry

Chem. J. Chinese Universities ›› 1992, Vol. 13 ›› Issue (5): 608.

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Determination of Morphine in Urine of Drug Addicts by Gas Chromatography-Mass Spectrometry

XU You-xuan¹, ZHU Shao-tang¹, ZHANG Chang-jiu¹, WU Yun¹, ZHANG You-jie²

1. National Research Institute of Sports Medkine, Beijing, 100029;
2. Analytical and Test Center of Center China Normal University, Wuhan

Received:1991-06-13 Online:1992-05-24 Published:1992-05-24

Abstract

Abstract: A rapid sensitive method has been developed for the determination of the concentration of morphine in drug addicts'urine by using GC/MScombined with Selected Ion Monitoring (SIM) technique.The peak area ratio of morphine to dihydrocodeine(internal standard) is proportional to the concentration of morphine from 10 ng/mLto 1000 ng/mL.The recovery and detection limit are 96.6±1.8(n=4) and 0.5 ng.The method has been used to determine the concentration of drug addicts who were being treated in a hospital.

Key words: Morphine, Drug addicts, Gas chromatography-mass spectrometry

TrendMD:

XU You-xuan, ZHU Shao-tang, ZHANG Chang-jiu, WU Yun, ZHANG You-jie. Determination of Morphine in Urine of Drug Addicts by Gas Chromatography-Mass Spectrometry[J]. Chem. J. Chinese Universities, 1992, 13(5): 608.

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Determination of Morphine in Urine of Drug Addicts by Gas Chromatography-Mass Spectrometry

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