Synthesis and Structure of p-Dimethylaminophenylgermanium Sesquioxide and Its Effect on the Mitotic Activity of Tumor Cell in Vitro

Chem. J. Chinese Universities ›› 1991, Vol. 12 ›› Issue (5): 573.

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Synthesis and Structure of p-Dimethylaminophenylgermanium Sesquioxide and Its Effect on the Mitotic Activity of Tumor Cell in Vitro

Zhang Shu-gong¹, Ni Jia-zuan¹, Niu Chun-ji¹, Nie Yu-xiu², Chen Yu-lan²

1. Changchun Institute of Applied Chemistry, Academia Sinica, Changchun, 130022;
2. Tissue Embryon Group, Norman Bethune University of Medical Sciences, Changchun

Received:1989-11-18 Online:1991-05-24 Published:1991-05-24

Abstract

Abstract: Under atomospheric pressure, the p-dimethylaminophenylgermanium sesquioxide was prepared. The characters of IR, XPS and TG-DTA show that the synthetic compound is the para-monogermanium substitued product. The sesquioxide possesses a higher polymerization degree than Ge-132.In the cell culture of breast carcinoma in vitro, the mitotic activity of tumor cell was obviously inhibited when the concentration of the compound is over 1. 0 mmol.

Key words: p-dimethylaminophenylgermanium sesquioxide, Synthesis, Spectrum, Structure, Antitu-mor reactivity

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Zhang Shu-gong, Ni Jia-zuan, Niu Chun-ji, Nie Yu-xiu, Chen Yu-lan. Synthesis and Structure of p-Dimethylaminophenylgermanium Sesquioxide and Its Effect on the Mitotic Activity of Tumor Cell in Vitro[J]. Chem. J. Chinese Universities, 1991, 12(5): 573.

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Synthesis and Structure of p-Dimethylaminophenylgermanium Sesquioxide and Its Effect on the Mitotic Activity of Tumor Cell in Vitro

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