Alkylation of Isopropyl 4-Chlorobenzenesulfonyl Acetate Under Phase Transfer Catalysis Condition

Abstract

Abstract: Alkylation of isopropyl 4-chlorobenzenesulfonyl acetate (1) with alkyl halides R¹X(R¹=n-Bu, CH₂=CHCH₂, p-CiC₆H₄CH₂, C₆H₅CH₂CH₂, C₆H₅CH₂; X=Cl, Br) in the system of K₂CO₃/DMF was carried out under solid-liquid phase transfer catalysis and five α-substituted products (2_a-e) were obtained. The monoalkylated products directly reacted with active alkyl halides R²X (R²: CH₂=CHCH₂, p-ClC₆H,CH₂, C₆H;CH₂; X=Cl, Br) in one-pot to give dialkylated compounds 3_n-t. This method has the advantage of moderate reaction conditions and high yields.

Key words: Phase transfer catalysis, Alkylation, Isopropyl 4-chlorobenzenesulfonyl acetate

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Zhang Li-kang, Zhang Zheng . Alkylation of Isopropyl 4-Chlorobenzenesulfonyl Acetate Under Phase Transfer Catalysis Condition[J]. Chem. J. Chinese Universities, 1991, 12(4): 491.

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Alkylation of Isopropyl 4-Chlorobenzenesulfonyl Acetate Under Phase Transfer Catalysis Condition

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