Synthesis of 2-Isopropyl-1,3-Dihydro-4(1H) Isoquinolone and Its Derivatives

Abstract

Abstract: Compound (2) was synthesized through condensation of ethyl N-isoproyl-N-(2-car-boethoxy benzyDglycinate. Compound (1) was obtained from the hydrolysis and decarboxylation of (2) in the presence of 18% HCl.Derivatives of (1), (3_a-6_e) were produced by condensation of (1) with benzaldehyde and p-substituted benzaldehyde, phenylhydrazines and oxime or (4) with benzoyl chlorides, respectively. Benzodiazepinone (7) was prepared by Beckmann rearrangement of (4) or reaction of (1) with NaN₃. Pyrazolo-isoquinolones(8_a-d) were synthesized through the condensation of (2) with hydrazine or substituted hydrazine, respectively. The structures of 20 new compounds have been confirmed by element analysis, IR and ¹HNMR.

Key words: Isoquinolone, Pyrazole, Benzodiazepinone

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Qian Jian-hua, Jiang Gui-ji . Synthesis of 2-Isopropyl-1,3-Dihydro-4(1H) Isoquinolone and Its Derivatives[J]. Chem. J. Chinese Universities, 1991, 12(12): 1620.

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Synthesis of 2-Isopropyl-1,3-Dihydro-4(1H) Isoquinolone and Its Derivatives

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