Investigation of Hydrolysis of Disubstituted Benzonitriles in Aqueous Mediums

Abstract

Abstract: Aseries of hydrolysis rate constants and activation energy of 6 disubstituted benzonitriles were determined at pH 10～14 and 40～80℃ by HPLC. The fate constants of these compounds at 25℃ were obtained by extrapolating. There is a linear relationship between lgk_B(k_B defined as hydroly-Sis rate constant for base-catalysis) and σ (Hammett Yett substituent constant) in the form of lgk_B=1. 45σ-0.859. Also, the relationship between lg k_B and pK_a(acid constant) was obtained in the form of lgk_B=1. 34pK_a-4.83.The resurts obtained are significant and useful to predicting the effects of all disubstituted behzoni-triles on the environrnent and can offer some scientific data for the risk-assessment and treatment of these organic pollutants.

Key words: Benzonitrile, Hydrolysis-, HPLC, Hammett Substituent constant, Regression equation

TrendMD:

Wang Liansheng, Yu Gang, Han Shuokui, Wang Aiguo, Zhang Zheng. Investigation of Hydrolysis of Disubstituted Benzonitriles in Aqueous Mediums[J]. Chem. J. Chinese Universities, 1990, 11(9): 988.

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Investigation of Hydrolysis of Disubstituted Benzonitriles in Aqueous Mediums

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