Abstract: The asymmetric condensation reactions of some thiophosphoryldichlorides 1 with(+)-1R, 3S-1,2,2-trimethyl^-1, 3-diamino-cyclopentane 2 have been investigated, and an excellent optically inductive effect of chiral reagent 2 appeared. Most products from the reactions were composed of two unequal amounts of diastereoisomers in which the chiral phosphorus atom formed in the reaction procedure had two opposite configurations of 3Rand 3S. The influences by the substituents of 1, temperature, solvents and time of the reactions have also been discussed.

Key words: Thiophosphoryldichloride, Asymmetric reaction, Diastereoisomer, Optical selectivity