Studies on Organosilicon Compounds with Biological Activity(Ⅷ)——Synthesis of 1-Alkylsilatranes and Study of Antitumour

Chem. J. Chinese Universities ›› 1988, Vol. 9 ›› Issue (5): 466.

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Studies on Organosilicon Compounds with Biological Activity(Ⅷ)——Synthesis of 1-Alkylsilatranes and Study of Antitumour

Wang Jitao¹, Xie Qinglan¹, Liao Renan¹, Li Jing¹, Li Baoyuan², Wang Shixian²

1. Institute of Elemento-Organic Chemistry, Nankai Univeisity, Tianjin;
2. Tianjin Institute of Medicinal Science, Tianjin

Received:1988-12-04 Online:1988-05-24 Published:1988-05-24

Abstract

Abstract: l-Alkylacyloxy-2,8,9-trioxa-5-aza-l-silatricyclo[3,3, 3, 0^1,5] undecanes (1-alkylacyloxysilatranes) were synthesized by the reaction of 1-brornosilatrane with organic acids. Compare with the method using 1-ethoxysilatrane reagent, this reaction gave higher yields and simpler process of treatment. The influence of reaction conditions was discussed. The ¹H NMRand 1Rof the title compounds were determined.The antitumour activity of some acyloxysilatranes was studied, one of them had good curative effects on Ehrlich cancer.

Key words: Silcon heterocyclic compound, Silatrane, Antitumour

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Wang Jitao, Xie Qinglan, Liao Renan, Li Jing, Li Baoyuan, Wang Shixian. Studies on Organosilicon Compounds with Biological Activity(Ⅷ)——Synthesis of 1-Alkylsilatranes and Study of Antitumour[J]. Chem. J. Chinese Universities, 1988, 9(5): 466.

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Studies on Organosilicon Compounds with Biological Activity(Ⅷ)——Synthesis of 1-Alkylsilatranes and Study of Antitumour

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