Inhibition of Crystal Formation and Aggregation of Calcium Bilirubinate with Disodium 1-Hydroxyethanediphosphonate(EHDP)

Abstract

Abstract: Disodium 1-hydroxyethanediphosphoriate was studied as an inhibitor of the formation and aggregation of calcium bilirubinate, the main component of pigment gallstone.The kinetics of calcium bilirubinate formation was studied at pH 7.9, 37+1℃, under nitrogen atmosphere, in the darkness. EHDPwas added in different levels, with or without choric acid. It is obvious that EHDPis able to inhibit the precipitation of calcium bilirubinate and the coexisted choric acid enhances this effect.The effect of EHDPon the particle size was also studied with Coulter counter. The results show that EHDPinhibit the aggregation effectively and a strong synergic effect was observed between EHDP and choric acid.

Key words: Disodium 1-hydroxyethanediphosphonate, Calcium bilirubinate, Inhibition

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Wang Kui, Xu Shanjin, Hu Jiaping, Cheng Tianrong, Jin Fan . Inhibition of Crystal Formation and Aggregation of Calcium Bilirubinate with Disodium 1-Hydroxyethanediphosphonate(EHDP)[J]. Chem. J. Chinese Universities, 1988, 9(12): 1207.

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Inhibition of Crystal Formation and Aggregation of Calcium Bilirubinate with Disodium 1-Hydroxyethanediphosphonate(EHDP)

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