Chem. J. Chinese Universities ›› 1986, Vol. 7 ›› Issue (4): 287.
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Qu Yun, Tang Wenxia, Dai Anbang
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Abstract: The title Pt-Guo compound was synthesized and isolated by the reaction between cis-CPt(NH3)2 (H2O)2]·(NO3)2 and guanosinc of mol ratio 1:1 in a neutral aqueous solution followed by careful purification with partial crystalization and rccrystallization from water at 0℃. The compound was characterized by elemental analysis, molecular weight determination, DTA, and 13C NMRspeclros-copy and its formula was found to be C{Pt(NH3)2}8(GuoH-1 )7(OH)2]·(NO3)7 · 8H2O.The isolation of the compound provides direct evidence for the intrastrand cross-linkage between Cisplatin and DNAthrough N7, N1 atoms of two adjacent guanines.
TrendMD:
Qu Yun, Tang Wenxia, Dai Anbang . Synthesis and Characterization of N7,N1 Cross-linkage Model Compound of Platinum and Guanosine[J]. Chem. J. Chinese Universities, 1986, 7(4): 287.
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http://www.cjcu.jlu.edu.cn/EN/Y1986/V7/I4/287
