Synthesis and Antibacterial Activities of Osthole Oxime Ether Derivatives

doi:10.7503/cjcu20250147

Chem. J. Chinese Universities

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Synthesis and Antibacterial Activities of Osthole Oxime Ether Derivatives

CHEN Yangmi, SHE Huixian, WAN Qing, YANG Jiaqiang

Guizhou Provincial Key Laboratory of Innovation and Manufacturing for Pharmaceuticals, School of Pharmacy, Zunyi Medical University

Received:2025-05-20 Revised:2025-06-22 Online First:2025-06-24 Published:2025-06-24
Contact: YANG Jiaqiang E-mail:yjqcn@126.com
Supported by:
Supported by the Guizhou Provincial Science and Technology Plan Project of China(No. Qiankehe Foundation ZK[2024]265) and the National College Students' innovation and entrepreneurship training program(No. 202310661006)

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Abstract

Abstract: Based on previous research, The structure of antibacterial active compound A were optimized using the scaffold hopping principle. Eighteen osthole oxime ether derivatives were designed and synthesized, and confirmed by ¹H NMR, ¹³C NMR and elemental analysis. The antibacterial activities test results revealed that these compounds had insignificant activity against S. aureus and E. coli. However, they unexpectedly exhibited good inhibitory effects against B. fragilis and P. anaerobius. Notably, the compounds 5d and 5g demonstrated the most significant activity, with minimum inhibitory concentrations(MIC) of 1 μg/mL and 2 μg/mL against B.fragilis, respectively. Its antibacterial activities are comparable to the control drug metronidazole, which will be extensively studied as novel antibacterial lead compounds.

Key words: Osthole derivatives, Oxime ether, Synthesis, Antibacterial activity

CLC Number:

O626

TrendMD:

CHEN Yangmi, SHE Huixian, WAN Qing, YANG Jiaqiang. Synthesis and Antibacterial Activities of Osthole Oxime Ether Derivatives[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20250147.

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Synthesis and Antibacterial Activities of Osthole Oxime Ether Derivatives

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