Synthesis of Multiaryl-substituted Mannich Base Catalysed by Silica-supported Rare Earth Samarium Chloride

doi:10.7503/cjcu20130255

Abstract

Abstract:

Many supported-catalysts are applied to the Mannich reaction, but they have disadvantages of low yield, unstability of supported rate and asking for long time. Silica-supported rare earth samarium chloride(SiO₂-OSmCl₂) was prepared by the reaction of silica and rare earth samarium chloride in toluene or CCl₄. The effects of different reaction conditions on the yields were investigated. This protocol has advantages of stability of supported rate, short time, mild condition, high yield, high selectivity, simple work-up, environmental friendly procedure and the catalyst can be reused. The three components of p-methoxyacetophenone, aromatic aldehydes and aromatic amines were reacted by one-pot Mannich reaction and catalysed by SiO₂-OSmCl₂ in ethanol at room temperature. As results, a series of new β-Amino carbonyl compounds were synthesized. The catalyst was characterized via IR and XRD, simultaneously the products were determined by IR, ¹H NMR and elemental analysis.

Key words: Silica-supported rare earth samarium chloride, β-Amino carbonyl compound, Mannich reaction

CLC Number:

O621.25⁺1

TrendMD:

MA Xue-Lin, ZHANG Xiao-Yong, YONG Sheng-Li, DUAN Li-Ping, WU Zhen-Yu. Synthesis of Multiaryl-substituted Mannich Base Catalysed by Silica-supported Rare Earth Samarium Chloride[J]. Chem. J. Chinese Universities, 2013, 34(12): 2759.

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