Synthesis and Photodynamic Antitumor Activity of New Metalloporphyrin-Ara-C Compounds

doi:10.7503/cjcu20130124

Abstract

Abstract:

Photodynamic therapy(PDT) is a promising modality with minimally invasive approach to the clinical treatment of oncology generally based on photosensitizers, as they can utilize the administration and selective accumulation in cancer tissues to cause tissue injury and cell death by exposure to suitable visible light. Porphyrins can be used as efficient photosensitizers with their unique characteristic π-system and coordinating metals. To develop new porphyrin photosensitizers of PDT, porphyrin-Ara-C compound was designed and synthesized, then four metalloporphyrin-Ara-C compounds were synthesized through metal insertion reaction. Their structures were characterized by ¹H NMR, IR, UV-Vis and MS. The photodynamic antitumor activity experimental results showed that the killing rate of PDT with 25μmol/L ZnAHP reacted for 30 min to MCF-7 cell could reach (45.86±8.20)%.

Key words: Ara-C, Metalloporphyrin, Photodynamic antitumor activity

CLC Number:

O621.3

TrendMD:

HE Jie, LIU Wen-Hong, HE Li-Min, CHEN Li-Yuan. Synthesis and Photodynamic Antitumor Activity of New Metalloporphyrin-Ara-C Compounds[J]. Chem. J. Chinese Universities, 2013, 34(10): 2308.

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