CJCU

Chem. J. Chinese Universities ›› 2013, Vol. 34 ›› Issue (3): 556.doi: 10.7503/cjcu20120677

• Analytical Chemistry • Previous Articles     Next Articles

Rapid Determination of Illegally Added β-Receptor Blockers in Traditional Medicines and Dietary Supplements by DCBI-MS Method

WANG Hua1, ZHAO Yong1, LIAO Peng1, WU Shuang1, HOU Yu-Lan1, SUN Wen-Jian2, DING Li2, CHEN Bo1   

  1. 1. Key Laboratory of Chemical Biology ﹠ Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China;
    2. Shimadzu Research Laboratory(Shanghai) Company, Ltd., Shanghai 201201, China
  • Received:2012-07-17 Online:2013-03-10 Published:2013-02-18

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Abstract:

A new rapid method was developed by coupling desorption corona beam ionization to ion trap mass spectrometer(DCBI-MS). Seven β-receptor blockers, i.e., atenolol, bisoprolol, metoprolol, propranolol, celiprolol hydrochloride, bevantolol hydrochloride and carvedilol that used be added illegally in antihyperten-sive traditional medicines and dietary supplements were detected. MS1 and MS2 spectra of the sample were employed for rapid screening and semi-quantitation of the target compound. Each aliquot was analyzed in 1 min. The limit of quantification(LOD) of analytes were all less than 0.1 mg/L and the dynamic linear range was 0.5—100 mg/L. The qualitative and semi-quantitative results were confirmed with the traditional HPLC-MS. With the proposed DCBI-MS method, one of 9 real samples was detected to contain the illicit additive of carvedilol. Both in quality control and illicit additive screening of the β-receptor blockers, the DCBI-MS technique can be a powerful tool due to its convenience and specificity.

Key words: Desorption corona beam ionization, Ion trap mass spectrometry, Traditional medicines, Dietary supplements, Rapid determination, β-receptor blockers

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