高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

含吡唑基的1,5-苯并硫氮杂衍生物的合成及晶体结构

邢烨1, 解正峰1, 刘方明2   

    1. 新疆大学石油天然气精细化工教育部重点实验室, 乌鲁木齐 830046;
    2. 杭州师范大学材料与化学化工学院, 杭州 310012
  • 收稿日期:2007-05-16 修回日期:1900-01-01 出版日期:2008-03-10 发布日期:2008-03-10
  • 通讯作者: 刘方明, 解正峰

Syntheses and Crystal Structure of 1,5-Benzothiazepine Derivatives Containing Pyrazole

XING Ye1, XIE Zheng-Feng1*, LIU Fang-Ming2*   

    1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, Xinjiang University, Urumqi 830046, China;
    2. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, China
  • Received:2007-05-16 Revised:1900-01-01 Online:2008-03-10 Published:2008-03-10
  • Contact: LIU Fang-Ming, XIE Zheng-Feng

PDF (PC)

被引次数

14

摘要： 以1-苯基-3-甲基-5-苯氧基-吡唑-4-甲醛和1-苯基-3-甲基-5-对甲苯氧基-吡唑-4-甲醛为原料, 在碱性条件下与苯乙酮(取代苯乙酮)发生羟醛缩合, 合成出10种新型含吡唑基的查尔酮; 再用此查尔酮与邻氨基硫酚在冰醋酸中反应, 合成了10种新的1,5-苯并硫氮杂, 化合物的结构经元素分析、IR和1H NMR确认, 同时测定了化合物6c的晶体结构. 化合物6c属单斜晶系(Monoclinic), 空间群P2(1)/n, 晶胞参数a=1.1793(2) nm, b=1.1907(2) nm, c=1.8726(4) nm, α=90°, β=104.71(3)°, γ=90°, M=522.04, V=2.5432(9) nm3, Dc=1.363 Mg/m3, Z=4, F(000)=1088.

关键词: 查尔酮, 1,5-苯并硫氮杂, 晶体结构

Abstract: Ten chalcones were synthesized by Aldol condensation reaction of acetophenone or para-substituted acetophenones with 1-phenyl-3-methyl-5-aryloxyl- pyrazol-4-aldehyde under the strong alkali condition, then chalcones reacted with 2-aminobenzenethiol in glacial acetic acid under refluxing to give a series of 1,5-benzothiazepine which have potentially useful pharmacological properties. The compounds were confirmed by means of elemental analysis, IR spectrum, 1H NMR and X-ray single-crystal diffraction analysis. The crystal of compound 6c belongs to a monoclinic system, space group P2(1)/n with cell parameters a=1.1793(2) nm, b=1.1907(2) nm, c=1.8726(4) nm, α=90°, β=104.71(3)°, γ=90°, M=522.04, V=2.5432(9) nm3, Dc=1.363 Mg/m3, Z=4, F(000)=1088.

Key words: Chalcone, 1,5-Benzothiazepine, Crystal structure

中图分类号: 

TrendMD: