高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

胶束增强型聚电解质胶囊对罗丹明B的包埋和释放

李晓东1,2, 沈家骢2   

    1. 浙江大学医学院附属口腔医院, 杭州 310006;
    2. 浙江大学高分子复合材料研究所, 杭州 310027
  • 收稿日期:2007-04-15 修回日期:1900-01-01 出版日期:2007-10-10 发布日期:2007-10-10
  • 通讯作者: 李晓东

Encapsulation and Release of the Micelles-enhanced PE Capsules Filled with Rhodamine B

LI Xiao-Dong1,2*, SHEN Jia-Cong2   

    1. Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China;
    2. Institute of Polymer Composite Material, Zhejiang University, Hangzhou 310027, China
  • Received:2007-04-15 Revised:1900-01-01 Online:2007-10-10 Published:2007-10-10
  • Contact: LI Xiao-Dong

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被引次数

17

摘要： 研究了胶束增强型的聚电解质胶囊对正电荷小分子罗丹明B的包埋和释放情况. 胶囊对正电荷水溶性物质罗丹明B的包埋动力学和包埋量的研究结果表明, 这种胶束增强型聚电解质胶囊能够快速而高效地包埋水溶性物质. 释放研究结果表明, 胶囊在不同的pH条件下的释放行为有一定的区别, 但趋势相同, 分为突释区、释放诱导区、快速释放区和缓释区, 呈现多区释放, 前期胶囊的突释现象相当明显. 同时, 盐离子的浓度对胶囊的释放行为影响不大.

关键词: LbL技术, 聚电解质微胶囊, 胶束增强, 高效包埋, 释放曲线

Abstract: The encapsulation of “micelles-enhanced” polyelectrolyte capsules to Rhodamine B, a positively charged small molecule, and in vitro release behavior of Rhodamine B containing capsules, were studied. Studies on the encapsulation kinetics and loading amount of capsules to water-soluble Rhodamine B suggest that water-soluble substances can be efficiently entraped into this type of “micelles-enhanced” polyelectrolyte capsules. In vitro release tests suggest that there were difference in release behavior between Rhodamine B-containing capsules that performed in release media with various pH values. However, for these release profiles, a similar trend was displayed, and the whole release curves have several periods with different Rhodamine B release rates, which include a burst release, a lag period, a rapid release phase and a sustained release stage. The burst release in the first stage was significant, which should be ameliorated in the following study. Simultaneously, ion strength seemed to have no significant effect on the release behavior of Rhodamine B-loaded capsules.

Key words: LbL technique, Polyelectrolyte capsule, Micelle enhancement, High efficient encapsulation, Release profile

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