高等学校化学学报

高等学校化学学报

• 研究简报 • 上一篇    下一篇

高耐光/耐化学性的核壳型荧光纳米微球的制备

胡振锟, 张青, 薛敏钊, 盛巧蓉, 刘燕刚   

  1. 上海交通大学化学化工学院精细化工研究所, 上海 200240
  • 收稿日期:2006-12-08 修回日期:1900-01-01 出版日期:2007-06-10 发布日期:2007-06-10
  • 通讯作者: 张青

Preparation of High-lightfastness/Chemical Resistance Core-shell-type Fluorescent Nanospheres

HU Zhen-Kun, ZHANG Qing*, XUE Min-Zhao, SHENG Qiao-Rong, LIU Yan-Gang   

  1. Institute of Fine Chemical Industry, School of Chemistry & Chemical Technology, Shanghai Jiaotong University, Shanghai 200240, China
  • Received:2006-12-08 Revised:1900-01-01 Online:2007-06-10 Published:2007-06-10
  • Contact: ZHANG Qing

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被引次数

9

摘要： 选取不溶于水的、光/热稳定性优良的荧光溶剂染料, 采用改进的细乳液(Miniemulsion)聚合反应, 将染料分子以分散状态牢固地嵌入交联的纳米聚合物基质中, 然后结合种子聚合反应技术构建生物相容性壳层, 制备出发射橙、黄、绿和青色光的系列核壳型荧光纳米微球. 获得的核壳型荧光纳米微球的平均粒径小于40 nm, 粒度较均一, 其水胶体具有优异的储存稳定性, 较高的光/化学稳定性和发光效率; 纳米微球的交联壳层表面富含与蛋白质、核酸等相容的羧基. 该制备方法简便可控, 原材料易得, 成本低廉, 也可选用含氨基、巯基和羟基等化学修饰基团的壳层单体来构建多样化的纳米微球壳层.

关键词: 核壳型荧光纳米微球, 水不溶性荧光染料, 改进的细乳液聚合反应, 种子聚合反应

Abstract: A class of core-shell-type fluorescent nanospheres with a particle diameter less than 40 nm, which emit orange, yellow, green and cyan light, respectively, were prepared. In fabricating strategy, the water-insoluble, photo-thermostable fluorescent dye molecules are molecularly dispersed and embedded in the nanoscale crosslinked polymeric matrix via a modified miniemulsion polymerization process, and then the biocompatible shells are achieved by a seeded polymerization technique. These obtained nanospheres are uniform in size, highly photostable, of high chemical resistance and high fluorescence quantum-yield.

Key words: Core-shell-type fluorescent nanospheres, Water-insoluble fluorescent dye, Modified miniemulsion polymerization, Seeded polymerization

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