高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (12): 2214.

• 研究论文 • 上一篇    下一篇

纳米Ag2O2-PbO2化学修饰电极对大肠杆菌细胞膜壁和DNA损伤的研究

顾静,张文,唐辉,金利通,左翼,吴自荣   

  1. 华东师范大学化学系,上海200062)(华东师范大学生命科学学院,上海200062
  • 收稿日期:2005-02-03 出版日期:1905-03-14 发布日期:1905-03-14
  • 通讯作者: 金利通(1937年出生),男,教授,博士生导师,主要从事生物电分析化学和环境分析化学研究.E-mail:ltjin@chem.ecnu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:20475017)和上海市技术委员会纳米技术专项基金(批准号:0452nm084)资助.

Studies on Nano Ag2O2-PbO2 Modified Electrode-induced Cell Membranes and DNA Damage of E.coli

GU Jing,ZHANG Wen,TANG Hui,JIN Li-Tong*,  ZUO Yi, WU Zi-Rong   

  1. Department of Chemistry,East China Normal University,Shanghai 200062,China
    College  of Life Science,East China Normal University,Shanghai 200062,China
  • Received:2005-02-03 Online:1905-03-14 Published:1905-03-14
  • Contact: JIN Li-Tong;E-mail:ltjin@chem.ecnu.edu.cn

摘要:

制备了一种新型纳米Ag2O2-PbO2修饰电极,在选定的正电位下,电极表面产生羟基自由基(·OH).通过测定产生的脂质过氧化物和漏出蛋白质的量来研究羟基自由基对大肠杆菌细胞膜壁损伤的情况,并运用电泳和DNA测序的方法对大肠杆菌质粒DNA的损伤及其对序列变化进行了研究.

关键词: 纳米Ag2O2-PbO2修饰电极;大肠杆菌;DNA损伤, 纳米AgO2-PbO2修饰电极, 大肠杆菌, DNA损伤

Abstract:

The fabrication of a novel nano Ag2O2-PbO2 modified electrode is described.Hydroxide radical could be generated on the surface of the  electrode at  an optimized potential.Lipid peroxidate and transudatory protein were detected to show destruction of cell membrane of E.coli treated by Ag2O2-PbO2 modified electrode.DNA damage of E.coli was  studied in detail with electrophoresis and DNA sequence determination.The results show that cracking of plasmid DNA and mutation of gene sequence could be induced by nano Ag2O2-PbO2 modified electrode.

Key words: Nano Ag2O2-PbO2 modified electrode;E.coli;DNA damage, Nano AgO2-PbO2 modified electrode, E.coli, DNA damage

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