双金属双硅层核-壳纳米结构Au@SiO2@Ag@SiO2用于葡萄糖检测

doi:10.7503/cjcu20180722

高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (5): 887.doi: 10.7503/cjcu20180722

双金属双硅层核-壳纳米结构Au@SiO₂@Ag@SiO₂用于葡萄糖检测

齐琪¹, 鲁冰新¹, 车玉萍¹, 汪洋², 翟锦¹()

1. 北京航空航天大学化学学院, 北京 100191
2. 中国科学院化学研究所, 北京 100190

收稿日期:2018-10-23 出版日期:2019-04-15 发布日期:2019-04-15
作者简介:
联系人简介: 翟锦, 女, 博士, 教授, 主要从事仿生光电转换纳米材料和器件研究. E-mail: zhaijin@buaa.edu.cn
基金资助:
国家重点研究发展计划项目(批准号: 2017YFA0206902,2017YFA0206900)、国家自然科学基金(批准号: 21471012,21771016)和国际科学和中国技术合作项目(批准号: 2014DFA52820)资助.

Bimetallic Multi-core Nanoparticles with Dual SiO₂ Layer Au@SiO₂@Ag@SiO₂ for the Detection of Glucose^†

QI Qi¹, LU Bingxin¹, CHE Yuping¹, WANG Yang², ZHAI Jin^1,^*()

1. School of Chemistry, Beihang University, Beijing 100191, China
2. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Received:2018-10-23 Online:2019-04-15 Published:2019-04-15
Contact: ZHAI Jin E-mail:zhaijin@buaa.edu.cn
Supported by:
† Supported by the National Key Research and Development Program of China(Nos.2017YFA0206902, 2017YFA0206900), the National Natural Science Foundation of China(Nos.21471012,21771016) and the International Science and Technology Cooperation Program of China(No.2014DFA52820)

摘要/Abstract

摘要：

制备了一种灵敏度高、稳定性强的双金属双硅层核-壳结构纳米材料Au@SiO₂@Ag@SiO₂. 由于双金属之间的硅层促进了远程等离子体的激发转移, 使该纳米粒子具有良好的表面增强拉曼散射(SERS)的特性及优异的稳定性. 利用这种SERS活性材料能直接检测出人体尿液的主要成分, 且该材料呈现出对低浓度(10^-6 mol/L)葡萄糖的无标记高效检出能力. 此外, 还实现了人工尿液中等浓度(10^-3 mol/L)葡萄糖和尿素分子的同时检测, 以及实际尿液中10^-3 mol/L葡萄糖的检测. Au@SiO₂@Ag@SiO₂纳米粒子具有在多种生物分子存在时快速检测葡萄糖的实际应用潜力.

关键词: Au@SiO₂@Ag@SiO₂, 表面增强拉曼散射, 无标记, 葡萄糖检测, 尿液

Abstract:

Surface-enhanced Raman scattering(SERS) was demonstrated as a highly efficient approach for the amplification of extremely low signals due to the strong electromagnetic field enhancement that occurs near closely-packed metallic nanostructures, which was dependent on the unique localized surface plasmon resonance(LSPR). To develop sensitive SERS probes, different geometric configurations as approaches are focusing on the synthesis of advanced nanostructures, or efficient Raman label compounds that are resonant with excitation light. These geometric factors affect the polarization direction and magnitude of plasmonic coupling and the SERS signal intensity. As we know, plasmonic properties of Au and Ag NPs are highly sensitive to their shapes. In order to improve the performance of metal nanoparticles in SERS detection, we prepared a highly sensitive and stable bimetallic double silicon core-shell nanostructured material of Au@SiO₂@Ag@SiO₂. The nanoparticles have good Raman scattering properties and excellent stability, since the silicon layer between the bimetals promotes remote plasma excitation transfer. The main component of human urine can be directly detected by using this SERS active material, and the material exhibits the ability to detect highly effectiveness 10^-6 mol/L glucose with label-free Au@SiO₂@Ag@SiO₂ nanoparticles. In addition, simultaneous detection of medium concentrations of 10^-3 mol/L glucose and urea molecules in artificial urine and detection of 10^-3 mol/L glucose in actual urine were also achieved. The Au@SiO₂@Ag@SiO₂ nanoparticles show the potential for detection glucose in the presence of multiple biomolecules.

Key words: Au@SiO₂@Ag@SiO₂, Surface-enhanced Raman scattering, Label-free, Detection of glucose, Urine

中图分类号:

O657

TrendMD:

齐琪, 鲁冰新, 车玉萍, 汪洋, 翟锦. 双金属双硅层核-壳纳米结构Au@SiO₂@Ag@SiO₂用于葡萄糖检测. 高等学校化学学报, 2019, 40(5): 887.

QI Qi,LU Bingxin,CHE Yuping,WANG Yang,ZHAI Jin. Bimetallic Multi-core Nanoparticles with Dual SiO₂ Layer Au@SiO₂@Ag@SiO₂ for the Detection of Glucose^†. Chem. J. Chinese Universities, 2019, 40(5): 887.

图/表 9

Fig.1 TEM images of Au@SiO2(A), Ag@SiO2(B) and Au@SiO2@Ag@SiO2(C, D)

Fig.2 HAADF-STEM images of Au@SiO2@Ag@SiO2(A, B), EDX mapping of O(C), Si(D), Ag(E) and Au(F)

Fig.3 SERS spectra of 10-6 mol/L crystal violet on Au@SiO2@Ag@SiO2, Ag@SiO2, Au@SiO2 and Au@SiO2@Ag nanoparticles(A) and average intensity at 808, 918, 1178, 1375 and 1621 cm-1(B)

Fig.4 Time course of intensity of 1178(a) and 1375 cm-1(b) peakInset: SERS spectra of 10-6 mol/L CV on Au@SiO2@Ag@SiO2 at 21 d.

Fig.5 Spectra of CV with 10-7 mol/L(a) and 10-8 mol/L(b) on Au@SiO2@Ag@SiO2 NPs

Fig.6 SERS(a) and regular Raman(b) spectra of urine sample

Fig.7 SERS spectra of glucose in artificial urine on Au@SiO2@Ag@SiO2 with various concentrations of glucose(A) and the nonlinear variation between SERS intensity and area vs. logarithmic plot of glucose concentration for the band at 1147 cm-1(B)(A) c(glucose)/(mol·L-1): a. 10-6; b. 10-5; c. 10-4; d. 10-3; e. 10-2.

Fig.8 Raman spectra of 10-3 mol/L(a) and 10-2 mol/L(b) urea and glucose

Fig.9 Raman spectra of real urine and glucosec(Glucose)/(mol·L-1): a. 10-3; b. 10-2; c. 10-1.

参考文献 30

[1]	Cardinal M. F., Rodríguezgonzález B., Alvarezpuebla R. A., Pérezjuste J., Lizmarzán L. M., J. Phys. Chem. C,2010, 114(23), 10417—104232
[2]	Jankovic V., Yang Y. M., You J. B., Dou L., Liu Y., Cheung P., ACS Nano,2013, 7(5), 3815—3822
[3]	Cho E. C., Camargo P. H., Xia Y., Adv. Mater.,2010, 22(6), 744—748
[4]	Xing S., Tan L.H., Chen T., Yang Y., Chen H.,Chem. Commun., 2009, (13), 1653—1654
[5]	Sharma B., Frontiera R. R., Henry A. I., Ringe E., Duyne R. P. V., Mater. Today,2012, 15(1/2), 16—25
[6]	Kelly K. L., Coronado E., Lin L. Z., Schatz G. C., Environ. Chem.,2003, 34(16), 668—677
[7]	Samal A. K., Polavarapu L., Rodal-Cedeira S., Liz-Marzán L. M., Pérez-Juste J., Pastoriza-Santos I., Langmuir,2013, 29(48), 15076—15082
[8]	Bu T. J., Ma X. W., Zhao B., Song W., Chem. Res. Chinese Universities,2018, 34(2), 290—295
[9]	Shen J., Zhu Y., Yang X., Zong J., Li C., Langmuir,2013, 29(2), 690—695
[10]	Feng J. J., Gernert U., Hildebrandt P., Weidinger I. M., Adv. Funct. Mater.,2010, 20(12), 1954—1961
[11]	Zhu J., Xu Z. J., Weng G. J., Zhao J., Li J. J., Zhao J. W., Spectrochim Acta A,2018, 200, 43—50
[12]	Chang H., Kang H., Yang J. K., Jo A., Lee H. Y., Lee Y. S., ACS Appl. Mater. Inter.,2014, 6(15), 11859—11863
[13]	Li J. F., Huang Y. F., Yang Z. L., Li S. B., Zhou X. S., Fan F. R., Nature,2010, 464(7287), 392—395
[14]	Scholl T. O., Sowers M. F., Chen X., Lenders C., Am. J. Epidemiol.,2001, 154(6), 514—520
[15]	Bruen D., Delaney C., Florea L., Diamond D., Sensors,2017, 17(8), 1866
[16]	Matzeu G., Florea L., Diamond D., Sensor. Actuat. B: Chem.,2015, 211, 403—418
[17]	Sun D., Qi G., Xu S., Xu W., RSC Adv.,2016, 6(59), 53800—53803
[18]	Gu X., Wang H., Schultz Z. D., Camden J. P., Anal. Chem.,2016, 88(14), 7191—7197
[19]	Kwon J. A., Jin C. M., Shin Y., Kim H. Y., Kim Y., Kang T., Appl. Mater. Interfaces,2018, 10, 13226—13235
[20]	Sun D., Liu X. Y., Xu S. P., Tian Y., Xu W. Q., Tao Y. C., Chem. Res. Chinese Universities,2018, 34(6), 899—904
[21]	Wang H., Malvadkar N., Koytek S., Bylander J., Reeves W. B., Demirel M. C., J. Biomed. Opt.,2010, 15(2), 027004
[22]	Lim D.K., Kim I. J., Nam J. M.,Chem. Commun., 2008, (42), 5312—5314
[23]	Bi G., Wang L., Cai C., Ueno K., Misawa H., Qiu J., J. Mod. Opt.,2014, 6(15), 1231—1235
[24]	Montalbán M., Coburn J., Lozano-Pérez A., Cenis J., Víllora G., Kaplan D., Nanomaterials,2018, 8(2), 126
[25]	Becker J., Zins I., Jakab A., Khalavka Y., Schubert O., Sönnichsen C., Nano Lett.,2008, 8,1719—1723
[26]	Deng Z., Chen M., Wu L., J. Phys. Chem. C,2007, 111(31),11692—11698
[27]	Premasiri W. R., Clarke R. H., Womble M. E., Laser. Surg. Med.,2010, 28(4), 330—334
[28]	Huang S., Wang L., Chen W., Feng S., Lin J., Huang Z., Laser. Phys. Lett.,2014, 11(11), 115604
[29]	Dong X. C., Xu H., Wang X. W., Huang Y. X., Chanpark M. B., Zhang H., ACS Nano,2012, 6(4), 3206—3213
[30]	Yonzon C. R., Lyandres O., Shah N. C., Dieringer J. A., Duyne R. P., Top. Appl. Phys.,2006, 103, 367—379

双金属双硅层核-壳纳米结构Au@SiO₂@Ag@SiO₂用于葡萄糖检测

Bimetallic Multi-core Nanoparticles with Dual SiO₂ Layer Au@SiO₂@Ag@SiO₂ for the Detection of Glucose^†

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 9

参考文献 30

相关文章 15

编辑推荐

Metrics

本文评价

[1]	夏大成, 周瑞, 涂博, 蔡志伟, 高难, 姬晓旭, 常钢, 任小明, 何云斌. 银/金纳米线阵列表面增强拉曼基底的制备及对孔雀石绿的高灵敏度检测[J]. 高等学校化学学报, 2022, 43(3): 20210731.
[2]	陈韶云, 张行颖, 刘奔, 田杜, 李奇, 陈芳, 胡成龙, 陈建. Ag纳米粒子在TiO₂四棱柱阵列上的可控生长及其SERS效应[J]. 高等学校化学学报, 2021, 42(8): 2381.
[3]	李奇, 田杜, 陈韶云, 钟敏, 胡成龙, 陈建. 银纳米片在无纺布纤维上的可控组装及其SERS效应[J]. 高等学校化学学报, 2021, 42(3): 736.
[4]	唐文涛, 李圣凯, 王昚, 陈龙, 陈卓. 基于激光介导富集的表面增强拉曼分析[J]. 高等学校化学学报, 2021, 42(10): 3054.
[5]	张梦瑶, 余仁鹏, 韩梅, 刘建芳, 李末霞, 胡家文, 田中群. 盐诱导金纳米粒子自组装和沉降制备具有宽波段吸收特性的黑金[J]. 高等学校化学学报, 2020, 41(8): 1903.
[6]	周海, 陈豪, 郭娅, 康敏. 介孔Co₃O₄多面体的制备及电化学性能[J]. 高等学校化学学报, 2019, 40(7): 1374.
[7]	王稳, 陶霞芳, 吴赟炎, 赵南, 程晓农, 杨娟, 周亚洲. 三明治结构纳米银/氧化石墨烯基底的制备及SERS性能[J]. 高等学校化学学报, 2019, 40(4): 667.
[8]	陈晓菲, 柳朝阳, 雷杨, 范宝安, 郭芬. Ni@MWCNTs催化阳极的制备及在直接尿素(尿液)燃料电池中的应用[J]. 高等学校化学学报, 2018, 39(3): 537.
[9]	徐蔚青, 管树霖, 王祎, 王馨楠, 陶艳春, 徐抒平. 一种保护层可揭除的新鲜多级银SERS活性基底[J]. 高等学校化学学报, 2018, 39(12): 2752.
[10]	马芳晨, 李欣, 任晓慧. 虚拟分子印迹与表面增强拉曼散射联用技术用于孔雀石绿的超灵敏检测[J]. 高等学校化学学报, 2017, 38(8): 1347.
[11]	江婷婷, 王远芳, 刘佩龙, 田义霞, 厉浩, 胡永国. 万古霉素修饰的硅包银纳米三角片在耐万古霉素肠球菌拉曼成像和光动力学抑菌治疗中的应用[J]. 高等学校化学学报, 2017, 38(5): 846.
[12]	张霞菲, 成锐, 时志路, 金燕. 基于链置换循环无标记检测端粒酶RNA的荧光法[J]. 高等学校化学学报, 2016, 37(1): 12.
[13]	徐布一, 叶懿, 阮若云, 颜有仪, 廖林川. 三维荧光光谱结合二阶校正算法用于尿液中常见毒品的检测[J]. 高等学校化学学报, 2015, 36(9): 1667.
[14]	陈雷, 薛向欣, 崔运成, 韩晓霞, 徐蔚青, 赵冰. 5,5'-二硫代双(琥珀酰亚氨基-2-硝基苯甲酸)功能化的SERS纳米探针在免疫检验中的应用[J]. 高等学校化学学报, 2015, 36(8): 1505.
[15]	刘培培, 韩晓霞, 赵冰, 徐蔚青, 王旭. 基于表面增强拉曼散射的敌草快检测方法[J]. 高等学校化学学报, 2015, 36(8): 1517.