高等学校化学学报 ›› 2017, Vol. 38 ›› Issue (8): 1489-1496.doi: 10.7503/cjcu20170008

• 高分子化学 • 上一篇    下一篇

基于β-环糊精接枝聚L-谷氨酸星型聚合物的可注射水凝胶的制备与表征

简宇航, 颜世峰, 李星, 黄亚南, 尹静波   

  1. 上海大学材料科学与工程学院高分子材料系, 上海 200444
  • 收稿日期:2017-01-05 修回日期:2017-05-03 出版日期:2017-08-10 发布日期:2017-05-03
  • 通讯作者: 颜世峰,男,博士,副研究员,主要从事生物医用和生态环境高分子材料研究.E-mail:yansf@staff.shu.edu.cn;尹静波,女,博士,教授,主要从事生物医用和生态环境高分子材料研究.E-mail:jbyin@oa.shu.edu.cn E-mail:yansf@staff.shu.edu.cn;jbyin@oa.shu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:51473090,51373094)、上海市自然科学基金(批准号:14ZR1414600)和上海市科学技术委员会基础研究项目(批准号:15JC1490400)资助.

Synthesis and Characterization of Injectable Hydrogels Based on Star β-CD-g-poly(L-glutamic acid)

JIAN Yuhang, YAN Shifeng, LI Xing, HUANG Yanan, YIN Jingbo   

  1. Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China
  • Received:2017-01-05 Revised:2017-05-03 Online:2017-08-10 Published:2017-05-03
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos. 51473090, 51373094), the Natural Science Foundation of Shanghai City, China(No. 14ZR1414600) and the Science and Technology Commission of Shanghai Municipality, China(No. 15JC1490400).

摘要:

采用Gadelle-Defaye法制备了全-6-氨基-β-环糊精[β-CD-(NH27],并用"Grafting-from"接枝法得到不同分子量的星型结构β-环糊精-g-聚L-谷氨酸(β-CD-g-PLGA).对β-CD-g-PLGA进行酰肼化改性后与醛基化海藻酸钠(ALG-CHO)通过席夫碱交联反应制备β-CD-g-PLGA/ALG水凝胶.研究了前驱体浓度以及β-CD-g-PLGA分子量对β-CD-g-PLGA/ALG水凝胶性能的影响,并以疏水性辛伐他汀(SIM)为模型药物,研究了水凝胶对SIM的控制释放行为.

关键词: 可注射水凝胶, β-环糊精, L-谷氨酸, 药物控释

Abstract:

A Gadelle-Defaye method was used to synthesis per-6-amino-β-CD[β-CD-(NH2)7]. Then, different molecular weighted star β-CD-g-poly(L-glutamic acid)(β-CD-g-PLGA-ADH) was synthesised via "grafting-from" method. The hydrogel precursors, β-CD-g-PLGA-ADH and oxided alginate(ALG-CHO) were mixed to prepare β-CD-g-PLGA/ALG hydrogel. The effect of solid content and molecular weight of β-CD-g-PLGA on the properties of hydrogel was studied. Simvastatin(SIM) was used as a model drug, the drug loading and release behavior of β-CD-g-PLGA/ALG hydrogel were researched. The introduction of β-CD into hydrogel made it an effective SIM loading and sustained release system.

Key words: Injectable hydrogel, β-Cyclodextrin, Poly(L-glutamic acid), Sustained drug release

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