端基为肝靶向基团的聚谷氨酸苄酯的合成及表征

高等学校化学学报 ›› 2006, Vol. 27 ›› Issue (5): 885.doi:

端基为肝靶向基团的聚谷氨酸苄酯的合成及表征

查瑞涛, 杜田, 袁直

功能高分子材料教育部重点实验室, 南开大学高分子化学研究所, 天津 300071

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-05-10 发布日期:2006-05-10
通讯作者: 袁直

Syntheses and Characterization of Poly(γ-benzyl-L-glutamate) Containing Liver Targeting Group in Main Chain

CHA RuiTao, DU Tian, YUAN Zhi*

Key Laboratory of Functional Polymer Materials, Ministry of Education，Institute of Polymer Chemistry, Nankai University, Tianjin 300071， China

Received:1900-01-01 Revised:1900-01-01 Online:2006-05-10 Published:2006-05-10
Contact: YUAN Zhi

摘要/Abstract

摘要：

本文研究甘草次酸、甘草酸和胆酸的二胺类衍生物的合成及其引发谷氨酸苄酯-N-羧酸酐的开环聚合, 合成了在端基具有不同肝靶向识别基团的聚谷氨酸苄酯. 该材料可能具有肝细胞主动靶向作用, 为进一步的肝靶向药物控释的研究奠定了基础.

关键词: 肝靶向; 甘草酸; 甘草次酸; 胆酸; 聚谷氨酸苄酯

Abstract:

tarted from the liver targeting compounds(glycyrrhizin, glycyrrhetinicacid, bile acid), six amine-terminated compounds were prepared via two-step reactions. The NMR experiments provided the direct evidence of the existence of amide. The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amineterminated compounds. The liver targeting group was introduced to the main chain of the polymer. The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator. The product structure was characterized by GPC, FTIR and ¹ H NMR. The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA.

Key words: Target of liver; Glycyrrhizin; Glycyrrhetinic acid; Bile acid; Poly(γ-benzyl-L-glutamate)

中图分类号:

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TrendMD:

查瑞涛, 杜田, 袁直 . 端基为肝靶向基团的聚谷氨酸苄酯的合成及表征. 高等学校化学学报, 2006, 27(5): 885.

CHA RuiTao, DU Tian, YUAN Zhi*. Syntheses and Characterization of Poly(γ-benzyl-L-glutamate) Containing Liver Targeting Group in Main Chain. Chem. J. Chinese Universities, 2006, 27(5): 885.