关键词: 邻甲酰胺基苯甲酰胺, 1,2,3-噻二唑, 晶体结构, 生物活性

Abstract: Since the public introduction of phthalic acid diamides and anthranilic diamides by Nihon Nohyaku, Bayer CropScience and DuPont, respectively, diamides have been the focus of synthesis in the field of agrochemical industry.Especially anthranilic diamides as insecticides, furthermore which also displayed good herbicidal and fungicidal activities, have recently attracted considerable attention. In the investigation of new agrochemicals, 1,2,3-thiadiazole derivatives often display good biological activities, and some diamides containing 1,2,3-thiadiazole possess good insecticide and fungicidal activities. In order to search for novel diamides which have high activities, a series of novel anthranilic diamides containing 1,2,3-thiadiazole were designed and synthesized, their structures were identified by means of elemental analysis, ¹H NMR, and the structure of compound 7g was determined by X-ray single crystal diffraction method. The preliminary results of biological activity experiment show that some of the title compounds exhibited a favourable fungicidal activity.

Key words: Anthranilic diamides, 1,2,3-Thiadiazole, Crystal structure, Biological activity