高等学校化学学报

高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (01): 22.doi: 10.3969/j.issn.0251-0790.2012.01.003

• 研究论文: 无机化学 • 上一篇    下一篇

聚乙二醇/羟基磷灰石纳米杂化材料的制备及表征

张鹏1, 杨兆钰1, 邱淑璇1, 丁克毅1, 罗建斌1, 谢兴益2   

  1. 1. 西南民族大学化学与环境保护工程学院, 成都 610041;
    2. 四川大学高分子科学与工程学院, 成都610065
  • 收稿日期:2011-05-09 出版日期:2012-01-10 发布日期:2011-12-20
  • 通讯作者: 罗建斌,男,博士,副教授,主要从事生物材料研究.E-mail:luojb1971@163.com E-mail:luojb1971@163.com
  • 基金资助:

    国家自然科学基金(批准号: 50973069)和国家外专局项目(批准号: Y-200902)资助.

Synthesis and Characterization of Poly(ethylene glycol)/hydroxyapatite Hybrid Nanomaterials

ZHANG Peng1, YANG Zhao-Yu1, QIU Shu-Xuan1, DING Ke-Yi1, LUO Jian-Bin1, XIE Xing-Yi2   

  1. 1. College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China;
    2. College of Polymer Science and Technology, Sichuan University, Chengdu 610065, China
  • Received:2011-05-09 Online:2012-01-10 Published:2011-12-20
  • Contact: LUO Jian-Bin E-mail:luojb1971@163.com

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被引次数

17

摘要： 以聚乙二醇单甲醚(MPEG)为原料, 采用先磷酰化再水解的方法合成了聚乙二醇单甲醚磷酸酯(P-MPEG). 以P-MPEG为空间位阻剂, 采用共沉淀法合成了内核为纳米羟基磷灰石(nHA)、 壳层为MPEG链的纳米杂化材料. 用傅里叶变换红外光谱(FTIR)、 X射线衍射(XRD)、 透射电子显微镜(TEM)和激光粒度分析(LPSA)对材料结构进行了表征. 结果表明, 所合成的杂化材料不仅能在水中再分散, 而且可以在甲醇和二甲基甲酰胺(DMF)等有机溶剂中再分散.

关键词: 聚乙二醇单甲醚磷酸酯, 空间位阻效应, 纳米羟基磷灰石, 再分散

Abstract: Poly(ethylene glycol ether) phosphate(P-MPEG) was synthesized through phosphorylating and hydrolyzing using poly(ethylene glycol methyl ether)(MPEG) as raw material. Then hybrid material with nHA core and polymer shell was synthesized through precipitation with P-MPEG as the steric hindrance agent. The nHA was characterized by Fourier transform infrared spectroscopy(FTIR), X-ray diffraction(XRD), transmission electron microscopy(TEM) and laser particle size analyzer(LPSA). The synthesized hybrid material is redispersible not only in water, but also in organic solvents such as methanol, N,N-dimethylformamide(DMF), etc. Feasibility of nHA with excellent redispersible ability using organic phosphate as the steric hindrance agent was confirmed.

Key words: Poly(ethylene glycol ether)phosphate, Steric hindrance effect, Nanohydroxyapatite, Redisperse

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