高等学校化学学报

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (5): 672.

• 论文 • 上一篇    下一篇

氯喹药物在水/1,2-二氯乙烷界面上的传输机理研究

肖俊, 林松, 聂利华, 姚守拙   

  1. 湖南大学化学化工系, 长沙, 410082
  • 收稿日期:1989-11-21 出版日期:1991-05-24 发布日期:1991-05-24
  • 通讯作者: 姚守拙
  • 基金资助:

    国家自然科学基金

Studies on Transfer Mechanism of Chloroquine at the Aqueous 1,2-Dichloroethane Interface

Xiao Jun, Lin Song, Nie Li-hua, Yao Shou-zhuo   

  1. Department of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082
  • Received:1989-11-21 Online:1991-05-24 Published:1991-05-24

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被引次数

1

摘要： 用滴电解液电极(EDE)极谱法、电流环扫伏安法和计时电位法研究了水相中氯喹离子、有机相中非离子化氯喹及以缔合物形式存在的氯喹在水/1,2-二氯乙烷界面上的传输过程.探讨了水相pH、氯喹浓度、EDE速度和扫描速度对传输行为的影响.提出了相应的传输机理.

关键词: 氯喹, 水/1, 2-二氯乙烷界面, 油/水界面, 离子传输

Abstract: Transfer processes of chloroquine in aqueous phase, non-ionized chloroquine and chloro-quine existing as ion-pair complex with tetraphenylborate in organic phase across the aqueous 1,2-CH2C1CH2C1interface were studied by polarography with the electrode of drop electrolyte (EDE), cyclic voltammetry with current scanning and chronopotentiometry, respectively. Their transfer mechanisms were proposed. The effect of pH of aqueous phase, the concentration of chloroquine and the flow-rate of EDE as well as the scanning rate on transfer behavior was discussed. The interfacial potential difference and Gibbs transfer energy were calculated as ΔDCEWφ=0. 06 V, ΔGtruo,DCE→W=-11. 58 kJ/mol, respectively.

Key words: Chloroquine, Water/1,2-dichloroethane interface, Oil/water interface, Ion transfer

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