高等学校化学学报 ›› 2021, Vol. 42 ›› Issue (11): 3265.doi: 10.7503/cjcu20210461
张亚青1, 李林瑶1, 郝梦琪1, 罗沁1, 邓思雨1, 杨芸1, 梁雪微2, 方威威1, 宋尔群1()
收稿日期:
2021-07-01
出版日期:
2021-11-10
发布日期:
2021-08-10
通讯作者:
宋尔群
E-mail:eqsong@swu.edu.cn
基金资助:
ZHANG Yaqing1, LI Linyao1, HAO Mengqi1, LUO Qin1, DENG Siyu1, YANG Yun1, LIANG Xuewei2, FANG Weiwei1, SONG Erqun1()
Received:
2021-07-01
Online:
2021-11-10
Published:
2021-08-10
Contact:
SONG Erqun
E-mail:eqsong@swu.edu.cn
摘要:
由致病菌或条件致病菌侵入机体繁殖而产生的毒素和其它代谢产物所引起的感染性疾病是目前全球范围内的主要死亡原因之一. 感染性疾病的早期诊断是对其进行有效治疗与控制的重要途径. 分子影像技术的快速发展给体内细菌感染的评估带来了前所未有的变化和机遇. 本文综合评述了计算机断层扫描、 正电子发射断层扫描、 超声成像、 磁共振成像、 荧光成像及光声成像等成像方式在细菌感染体内成像中的研究进展、 不足和发展方向等, 以期为活体细菌感染检测方法的发展提供参考.
中图分类号:
TrendMD:
张亚青, 李林瑶, 郝梦琪, 罗沁, 邓思雨, 杨芸, 梁雪微, 方威威, 宋尔群. 细菌感染成像的研究进展. 高等学校化学学报, 2021, 42(11): 3265.
ZHANG Yaqing, LI Linyao, HAO Mengqi, LUO Qin, DENG Siyu, YANG Yun, LIANG Xuewei, FANG Weiwei, SONG Erqun. Research Progress of Bacterial Infection Imaging. Chem. J. Chinese Universities, 2021, 42(11): 3265.
Fig.1 Schematic illustration of the application of the Bi2S3@mSiO2@Ag for CT imaging and antibacterial treatment of the gastrointestinal(GI) tract[15]Copyright 2020, the Royal Society of Chemistry.
Fig.4 Schematic illustration of the application of the Ga?based(A)[43] and Mn?based(B)[44] MRI contrast agents for bacterial infection imaging and MRI guided treatment(A) Copyright 2018, American Chemical Society; (B) Copyright 2021, Elsevier.
Fig.5 Schematic illustration of the application of fluorescently labeled maltohexaose(A)[55], Vanco?800CW(B)[50], TPACN?D?Ala(C)[64] and AIEgen?peptide(D)[52] for fluorescence imaging of bacterial infection(A) Copyright 2011, Springer Nature; (B) Copyright 2013, Springer Nature; (C) Copyright 2020, the Royal Society of Chemistry; (D) Copyright 2020, the Royal Society of Chemistry.
Fig.6 Schematic illustration of AuNPs@P1(A)[66] and Ppa?PLGVRG?Van(B)[68] based PAI contrast agentfor bacterial infection imaging(A) Copyright 2020, Wiley?VCH; (B) Copyright 2016, Wiley?VCH.
Imaging modality | Imaging information | Advantage | Disadvantage |
---|---|---|---|
CT[ | Anatomical | High spatial resolution; good anatomical structure | Radioactive; pool soft tissue discrimination |
PET[ | Physiological | High sensitivity; quantitative | Radioactive; low spatial resolution |
US[ | Anatomical; physiological | Good spatial resolution; portable | Lacking available probe |
MRI[ | Anatomical; physiological | Good spatial resolution; superb soft tissue discrimination | Long imaging time; low sensitivity |
FL[ | Physiological | High sensitivity; low equipment requirements | Limited imaging depth |
PAI[ | Physiological | Good contrast and resolution | Limited imaging in bone and air tissue |
Table 1 Performance comparison of common bacterial imaging technology
Imaging modality | Imaging information | Advantage | Disadvantage |
---|---|---|---|
CT[ | Anatomical | High spatial resolution; good anatomical structure | Radioactive; pool soft tissue discrimination |
PET[ | Physiological | High sensitivity; quantitative | Radioactive; low spatial resolution |
US[ | Anatomical; physiological | Good spatial resolution; portable | Lacking available probe |
MRI[ | Anatomical; physiological | Good spatial resolution; superb soft tissue discrimination | Long imaging time; low sensitivity |
FL[ | Physiological | High sensitivity; low equipment requirements | Limited imaging depth |
PAI[ | Physiological | Good contrast and resolution | Limited imaging in bone and air tissue |
Fig.7 Schematic illustration of the application of 99mTc?UBI29-41?Cy5(A)[5] and MBP?Ce6 NSs(B)[74] for multimodal imaging of bacterial infections(A) Copyright 2019, American Chemical Society; (B) Copyright 2020, AAAS.
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[1] | 张兵波, 宫晓群, 李卓权, 郭方方, 蔡少瑜, 孔继烈, 杨秋花, 马浩, 常津, 时东陆. 用于疾病诊断的GdⅢ/量子点多模态成像探针的构建[J]. 高等学校化学学报, 2010, 31(5): 982. |
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