硬段侧链含有氟化双季铵盐的聚氨酯表面性能及抗菌性能分析

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (6): 1268.

硬段侧链含有氟化双季铵盐的聚氨酯表面性能及抗菌性能分析

罗建斌, 马晨, 廖戎, 万静, 张鹏, 张杰

西南民族大学化学与环境保护工程学院, 成都 610041

收稿日期:2009-09-14 出版日期:2010-06-10 发布日期:2010-06-10
通讯作者: 罗建斌, 男, 博士, 副教授, 主要从事生物材料的研究. E-mail: luojb1971@163.com
基金资助:
西南民族大学青年重点基金(批准号: 26701701)资助.

Surface and Antibacterial Properties of Polyurethane with Fluorinated Bis-ammonium Salts Attached to Hard Segments

LUO Jian-Bin*, MA Chen, LIAO Rong, WAN Jing, ZHANG Peng, ZHANG Jie

College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China

Received:2009-09-14 Online:2010-06-10 Published:2010-06-10
Contact: LUO Jian-Bin. E-mail: luojb1971@163.com
Supported by:
西南民族大学青年重点基金(批准号: 26701701)资助.

摘要/Abstract

摘要：

研究了硬段侧链含有氟化双季铵盐的系列聚氨酯(FQPUs)的表面性能和抗菌性能. 水接触角测试和表面自由能测试结果表明, 加入少量氟化双季铵盐扩链剂, 可以使聚氨酯表面富集氟碳链, 氟化双季铵盐聚氨酯表面自由能很低, 具有很好的抗黏附性能. 迁移到表面的两条氟碳链在常温下不会发生链反转, 使材料的抗黏附性能得以保持. 同时, 使材料表面形成一层疏水层, 减小材料的吸水率. XPS研究结果表明, 氟碳链的—CF₃位于材料的最外层, 材料的次表面是具有良好杀菌性能的双季铵盐, 这样形成了具有多重抗菌性能的表面. 另外, XPS研究结果表明, 材料表面化学结构与材料本体的微相分离结构相关. 抗菌性能测试结果表明, 氟化双季铵盐聚氨酯抗金黄色葡萄球菌的能力很强, 对于大肠杆菌的抗菌效果有所下降, 但相对于单季铵盐聚氨酯的抗菌效果有一定提高.

关键词: 氟化双季铵盐; 聚氨酯; 抗菌; 表面性能

Abstract:

The surface properties of the novel polyurethanes with fluorinated bis-ammonium salts group(FQPUs) were studied by contact angle test and XPS test. For polyurethanes with pendant fluorinated bis-ammonium salts, addition of little fluorinated bis-ammonium salts chain extender(EDF) made the polyurethane surface saturated with ammonium salts and fluorinated chains. The fluorinated alkyl chains endowed polyurethane with very low surface energy and antibacterial adhesion properties as proven by surface free energy test. Water contact angle demonstrated that the fluorinated chains could not overturn and the antibacterial adhesion properties of polyurethane would be maintained. Moreover, this properties can make polyurethane with lower water adsorption. It was found by plate count that polyurethanes with fluorinated bis-ammonium salts chain extender(EDF)(FQPUs) all had excellent antibacterial properties against gram positive bacteria, i.e. S. aureus and a little lower antibacterial properties against gram-negative bacteria, i.e. E. coli.

Key words: Fluorinated bis-ammonium salt; Polyurethane; Antibacterial; Surface property

TrendMD:

罗建斌, 马晨, 廖戎, 万静, 张鹏, 张杰. 硬段侧链含有氟化双季铵盐的聚氨酯表面性能及抗菌性能分析. 高等学校化学学报, 2010, 31(6): 1268.

LUO Jian-Bin*, MA Chen, LIAO Rong, WAN Jing, ZHANG Peng, ZHANG Jie. Surface and Antibacterial Properties of Polyurethane with Fluorinated Bis-ammonium Salts Attached to Hard Segments. Chem. J. Chinese Universities, 2010, 31(6): 1268.

参考文献

[1]Lelah M. D., Cooper S. L.. Polyurethane in Medicine[M], Boca Raton, FL: CRC Press, 1986: 57—110
[2]John T., Maureen S., Adrian A.. Biomaterials[J], 1999, 20: 1229—1235
[3]Quirynen M., Marechal M., Busscher H. J., Weerkamp A. H., Arends J., Darius P. L., van Steenberghe D.. J. Dent. Res.[J], 1989, 68: 796—799
[4]Bakker D. P., Huijs F. M., De Vries J., Klijnstra J. W., Busscher H. J., van der Mei H. C.. Colloids and Surfaces B: Biointerfaces[J], 2003, 32: 179—190
[5]Gottenbos B., Van de Mei H. C., Busscher H. J.. Journal of Biomedical Materials Research[J], 2000, 50: 208—214
[6]Acharya V., Ratna Prabha C., Narayanamurthy C.. Biomaterials[J], 2004, 25: 4555—4562
[7]Grapski J. A., Cooper S. L.. Biomaterials[J], 2001, 22: 2239—2246
[8]Menger F. M., Keiper J. S.. Angew. Chem. Int. Ed.[J], 2000, 39: 1906—1920
[9]LUO Jian-Bin(罗建斌), LI Jie(李杰), LI Jie-Hua(李洁华), TAN Hong(谭鸿), ZHONG Yin-Ping(钟银屏). Journal of Sichuan University(Engineering Science Edition)(四川大学学报(工程科学版))[J], 2007, 39(6): 91—95
[10]LUO Jian-Bin(罗建斌), LI Jie-Hua(李洁华), MA Chen(马晨), TAN Hong(谭鸿), Chinese Journal of Biomedical Engineering(中国生物医学工程学报)[J], 2008, 27(5): 760—763
[11]LUO Jian-Bin, WANG Qiang, TAN Hong, LI Jie-Hua, ZHONG Yin-Ping. Chinese Chemical Letters[J], 2006, 11(17):1423—1426
[12]Luo Jian-Bin, 2009 2nd International Conference On Biomedical Engineering and Informatics[C], Tianjin, 2009, 1157—1160
[13]Flemming R. G., Christopher C. C., Cooper S. L., Proctor R. A.. Biomaterials[J], 2000, 21: 273—281
[14]Shao Hui, Meng Wei-Dong, Qing Feng-Ling. Journal of Fluorine Chemistry[J], 2004, 125: 721—724
[15]McCloskey C. B., Yip C. M., Santerre J. P.. Macromolecules[J], 2002, 26: 924—933
[16]Game P., Sage D., Chapel J. P.. Macromolecules[J], 2002, 35: 917—923
[17]John T., Maureen Stone, Adrian A. Thorpe, Biomaterials[J], 1999, 20: 1229—1235
[18]Zhang Jun, Yuan Jiang, Yuan You-Ling, Zang Xiao-Peng, Shen Jian, Lin Si-Cong. Biomaterials[J], 2003, 24: 4223—4231
[19]Zhang Z., Marois Y., Guidoin R. G., Bull P., Marois M., How T., Laroche G., King M. W.. Biomaterials[J], 1997, 18(2): 113—124
[20]Patric Jannasch, Macromolecules[J], 1998, 31: 1341—1347