高等学校化学学报

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (6): 1093.

• 研究论文 • 上一篇    下一篇

多孔羟基磷灰石纳米球作为抗坏血酸载体的研究

邵锋伟, 蔡玉荣, 姚菊明   

  1. 浙江理工大学材料与纺织学院, 教育部先进纺织材料与制备技术重点实验室, 杭州 310018
  • 收稿日期:2009-11-05 出版日期:2010-06-10 发布日期:2010-06-10
  • 通讯作者: 姚菊明, 男, 博士, 教授, 主要从事生物材料研究. E-mail: yaoj@zstu.edu.cn
  • 基金资助:

    长江学者和创新团队发展计划(批准号: IRT0654), 新世纪优秀人才支持计划(批准号: NCET070763)和钱江人才计划(批准号: 2008R10006)资助.

Porous Hydroxyapatite Nanoparticles as a Carrier of Ascorbic Acid

SHAO Feng-Wei, CAI Yu-Rong, YAO Ju-Ming*   

  1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, China

  • Received:2009-11-05 Online:2010-06-10 Published:2010-06-10
  • Contact: YAO Ju-Ming. E-mail: yaoj@zstu.edu.cn
  • Supported by:

    长江学者和创新团队发展计划(批准号: IRT0654), 新世纪优秀人才支持计划(批准号: NCET070763)和钱江人才计划(批准号: 2008R10006)资助.

PDF (PC)

被引次数

15

摘要：

利用超声辅助的化学共沉淀法制备了羟基磷灰石纳米材料, 并实现了其对抗坏血酸的包载. 采用透射电镜、氮气吸附孔径分析仪、X射线粉末衍射仪、傅里叶红外光谱仪和紫外分光光度计等对所得纳米材料的微观形貌、孔径分布、物相、表面官能团和负载抗坏血酸量进行了表征和分析, 并在超声辅助条件下进行了药物释放动力学研究. 结果表明, 在抗坏血酸存在的条件下, 利用声化学方法可以制得多孔的羟基磷灰石纳米球, 其平均直径约为140 nm, 平均孔直径约为15 nm, 可实现对抗坏血酸的包载. 此外, 在超声辅助的条件下, 该纳米球具有持续释药的能力, 不同的超声功率能改变载药粒的释药速度, 表明这种多孔羟基磷灰石纳米球是一种具有很大应用前景的骨组织药物载体.

关键词: 药物载体; 羟基磷灰石; 抗坏血酸; 控释

Abstract:

Hydroxyapatite(HAP) is the most important ceramic material for biomedical applications for drug carrier and bone fillers because of its similarity to the biominerals in bone and hard tissues in mammals. It is one of few materials that are classed as bioactive, meaning that it will support bone ingrowth and osseointegration when used in orthopaedic applications. In this work, HAP nanoparticles were fabricated by chemical co-precipitation method with the assistant of the ultrasonic treatment in the present of ascorbic acid(AA). The as-prepared HAP nanoparticles were characterized by TEM, nitrogen adsorption, XRD, FTIR and ultraviolet spectrophotometer. The results showed that the porous HAP nanoparticles were obtained, which had an average diameter of about 140 nm and an average pore diameter of about 15 nm. The porous particles could load AA and the release speed of AA could be controlled by the ultrasonic treatment with different powers. This work indicated that the porous HAP nanoparticle was a promising candidate for drug carrier.

Key words: Drug carrier; Hydroxyapatite; Ascorbic acid; Controlled release

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