高等学校化学学报

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (4): 731.

• 研究论文 • 上一篇    下一篇

云南萝芙木叶吲哚生物碱

耿长安1,2, 刘锡葵1   

  1. 1. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室, 昆明 650204;
    2. 中国科学院研究生院, 北京 100049
  • 收稿日期:2009-05-05 出版日期:2010-04-10 发布日期:2010-04-10
  • 通讯作者: 刘锡葵, 男, 副研究员, 主要从事天然产物持续利用研究. E-mail: liuxikui@mail.kib.ac.cn
  • 基金资助:

    云南省自然科学基金(批准号: 2006C0010Z)资助.

Indole Alkaloids from the Leaves of Rauvolfia yunnanensis

GENG Chang-An1,2, LIU Xi-Kui1*   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;
    2. Graduate School of the Chinese Academy of Science, Beijing 100049, China
  • Received:2009-05-05 Online:2010-04-10 Published:2010-04-10
  • Contact: LIU Xi-Kui. E-mail: liuxikui@mail.kib.ac.cn
  • Supported by:

    云南省自然科学基金(批准号: 2006C0010Z)资助.

PDF (PC)

被引次数

9

摘要：

从栽培云南萝芙木(Rauvolfia yunnanensis Tsiang)叶的95%乙醇提取物中分离得到11个吲哚类生物碱: Caberine(1), 19-Ethoxyl-1-demethyl-Δ1-17-acetylajmaline(2), Vellosimine(3), β-Yohimbine(4), Yohimbine(5), Vinorine(6), Picrinine(7), Nareline(8), Akuammicine(9), Strictamine(10), Reserpine(11). 采用UV, IR, MS和1D, 2D NMR方法对它们的结构进行了鉴定, 其中化合物2为新的吲哚生物碱, 化合物1, 8和9为首次从该属植物中分离得到.

关键词: 云南萝芙木; 吲哚生物碱; 19-Ethoxyl-1-demethyl-Δ1-17-acetylajmaline; Caberine; 利血平; 育亨宾

Abstract:

Rauvolfia yunnanensis Tsiang are commonly used as a folklore herb to treat hypertension, snake bites, and insanity in the southwest of China, and an important industrial raw material of reserpine and vertical. But the wild resources of it reduced gradually in recent years, thus we have introduced and cultivated it to the arid-hot valley region of Yunnan Province, China, and investigated the chemical constituents variety of it for the sustainable utilization. The dried leaves powder(8.0 kg) of R. yunnanensis was extracted with 95%(volume fraction) EtOH(40 L×5 , 8 h each), and led to the isolation of eleven indole alkaloids by column chromatography(silica, alumina and Sephadex LH-20 gel) methods. Their structures were identified as caberine(1), 19-ethoxyl-1-demethyl-Δ1-17-acetylajmaline(2), vellosimine(3), β-yohimbine(4), yohimbine(5), vinorine(6), picrinine(7), nareline(8), akuammicine(9), strictamine(10), reserpine(11) by spectral analysis(UV, IR, MS and 1D, 2D NMR), respectively. Among them, compound 2 was a new indole alkaloids, compounds 1, 8 and 9 were firstly isolated from this plant.

Key words: Rauvolfia yunnanensis; Indole alkaloid; 19-Ethoxyl-1-demethyl-Δ1-17-acetylajmaline; Caberine; Reserpine; Yohimbine

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