高等学校化学学报

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (12): 2344.

• 研究论文 • 上一篇    下一篇

Ho(III)希夫碱大环配合物的合成、晶体结构及对DNA的切割活性

王银平, 吴起峰, 夏雨佳, 胡学雷, 潘志权   

  1. 武汉工程大学绿色化工过程省部共建教育部重点实验室, 湖北省新型反应器与绿色化学工艺重点实验室, 武汉 430073
  • 收稿日期:2010-04-29 修回日期:2010-08-15 出版日期:2010-12-10 发布日期:2010-12-06
  • 通讯作者: 胡学雷 E-mail:huxuelei@mail.wit.edu.cn
  • 作者简介:胡学雷, 男, 博士, 教授, 主要从事配位化学的研究. E-mail: huxuelei@mail.wit.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:  20671075)资助.

Synthesis, Crystal Structure and DNA Cleavage of a New Holmium(III) Nitrate with a Schiff-based Macrocyclic Ligand

WANG Yin-Ping,  WU Qi-Feng,  XIA Yu-Jia, HU Xue-Lei*,  PAN Zhi-Quan   

  1. Key Laboratory for Green Chemical Process, Ministry of Education, Key Laboratory of Novel Chemical Reactor and Green Chemical Technology of Hubei Province, Wuhan Institute of Technology, Wuhan 430073, China
  • Received:2010-04-29 Revised:2010-08-15 Online:2010-12-10 Published:2010-12-06
  • Contact: HU Xue-Lei E-mail:huxuelei@mail.wit.edu.cn
  • About author:胡学雷, 男, 博士, 教授, 主要从事配位化学的研究. E-mail: huxuelei@mail.wit.edu.cn
  • Supported by:

    国家自然科学基金(批准号:  20671075)资助.

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被引次数

10

摘要： 本文合成一个新的希夫碱大环配体硝酸Ho(III)配合物 [Ho(H2L)(NO3)2](NO3) (H2L表示大环配体Fig. 1)，并进行了系统的物理表征. 晶体结构研究表明: 配合物晶体结构属六方晶系，P 3(1)21空间群，晶胞参数a=1.47213(7) nm，c=2.8998(3) nm，α=90°，γ=120°，V=5.4424(7) nm 3，Z=6，R＝0.0331, wR＝0.0928。中心离子Ho3+位于隔室大环配体的一侧并于希夫碱大环上的两个酚基氧原子和三个氮原子配位，两个双齿配位硝酸根分别从希夫碱大环平面的两侧与中心离子配位使中心离子形成扭曲的九配位三冠三棱柱配位构型。并通过凝胶电泳实验初步研究了该配合物对pBR322质粒DNA的切割作用。

关键词: 大环配体, 硝酸钬配合物；合成；晶体结构；DNA切割；

Abstract: The title macrocyclic complex [Ho(H2L)(NO3)2](NO3) (H2L denotes the macrocyclic ligand, Fig. 1) has been synthesized and characterized by elemental analysis, infrared spectra, and electrospray mass spectra. Its crystal and molecular structures were determined by X-ray diffraction methods. The crystal crystallizes in the hexagonal system, space group P3(1)21 with a=1.47213(7) nm， c=2.8998(3) nm，α=90°，γ=120°，V=5.4424(7) nm 3，Z=6，R＝0.0331, wR＝0.0928。 The central holmium ion was located in one of the compartments of the macrocyclic ligand and was coordinated with two oxygen and three nitrogen atoms of the macrocycle. Two nitrates were chelated in the opposite positions of the macrocycle, and the third one is ionic. So the central ion presented a distorted tricapped trigonal prismatic coordination geometry. The preliminary studies of cleavage of double stranded DNA was demonstrated by electrophoresis gel.

Key words: macrocyclic ligand, holmium nitrate complex；synthesis；crystal structure；DNA cleavage

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