利用酶促开环聚合和原子转移自由基聚合方法合成AB型嵌段共聚物

高等学校化学学报 ›› 2006, Vol. 27 ›› Issue (5): 985.doi:

利用酶促开环聚合和原子转移自由基聚合方法合成AB型嵌段共聚物

沙柯, 李冬霜, 李亚鹏, 刘啸天, 艾鹏, 王薇, 王静媛

吉林大学化学学院, 麦克德尔米德实验室, 长春 130023

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-05-10 发布日期:2006-05-10
通讯作者: 王静媛

Synthesis and Characterization of AB-Type Diblock Copolymer by Enzymatic Ring-opening Polymerization and ATRP

SHA Ke, LI Dong-Shuang, LI Ya-Peng, LIU Xiao-Tian, AI Peng, WANG Wei, WANG Jing-Yuan*

Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, Changchun 130023, China

Received:1900-01-01 Revised:1900-01-01 Online:2006-05-10 Published:2006-05-10
Contact: WANG Jing-Yuan

摘要/Abstract

摘要：

我们用端基官能化方法实现两种聚合反应的结合, 成功地制备了AB型双嵌段共聚物PCL-b-PSt和BAB型三嵌段共聚物PSt-b-PCL-b-PSt. 本文利用上述方法, 将酶促开环聚合和原子转移自由基聚合有机地结合起来, 合成了AB型嵌段共聚物-聚己内酯/聚甲基丙烯酸环氧丙酯(PCL-b-PGMA. 此嵌段共聚物具有良好的生物相容性, 在现代生物领域具有广泛的应用前景.

关键词: 酶促开环聚合; 原子转移自由基聚合(ATRP); 嵌段共聚物; 固定化酶Novozyme 435

Abstract:

Mono-hydroxyl terminated polycaprolactone(PCL) was prepared by Novozyme 435 catalyzed ring-opening polymerization(ROP) of ε-caprolactone(ε-CL) initiated by methanol, and subsequently converted to bromine ended PCL by the esterification of the resulting macromolecules with α-bromopropionyl bromide. The macroinitiators containing α-bromoester group were employed in the atom transfer radical polymerization(ATRP) of glycidyl methacrylate(GMA) with CuCl/2,2-bipyridine(bpy) as the catalyst system to obtain amphiphilic diblock copolymer PCL-b-PGMA.

Key words: Enzyme-promoting rin-, opening polymerization; Atom transfer radical polymerization(ATRP); Block copolymer; Fixed enzyme Novozyme 435

中图分类号:

O632
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TrendMD:

沙柯, 李冬霜, 李亚鹏, 刘啸天, 艾鹏, 王薇, 王静媛 . 利用酶促开环聚合和原子转移自由基聚合方法合成AB型嵌段共聚物. 高等学校化学学报, 2006, 27(5): 985.

SHA Ke, LI Dong-Shuang, LI Ya-Peng, LIU Xiao-Tian, AI Peng, WANG Wei, WANG Jing-Yuan*. Synthesis and Characterization of AB-Type Diblock Copolymer by Enzymatic Ring-opening Polymerization and ATRP. Chem. J. Chinese Universities, 2006, 27(5): 985.