高分子量的聚L-谷氨酸的合成与表征

高等学校化学学报 ›› 2006, Vol. 27 ›› Issue (2): 369.

高分子量的聚L-谷氨酸的合成与表征

曹田¹, 尹静波¹, 罗坤¹, 陈红丹¹, 陈学思²

1. 上海大学材料学院高分子系, 上海 201800;
2. 中国科学院长春应用化学研究所高分子物理与化学国家重点实验室, 长春 130022

收稿日期:2005-02-21 出版日期:2006-02-10 发布日期:2006-02-10
通讯作者: 陈学思, xschen@ciac.jl.cn; 尹静波，jbyin@staff.shu.edu.cn
基金资助:
国家自然科学基金(批准号: 50473061), 上海市教委发展基金(批准号： 03AK21)和上海市科委基础研究重点项目(批准号: 05JC14067)资助.

Synthesis and Characterization of Poly-L-glutamic Acid with a High Molecular Weight

CAO Tian ¹, YIN Jing-Bo¹, LUO Kun¹, CHEN Hong-Dan¹, CHEN Xue-Si²

1. Department of Polymer, Shanghai University, Shanghai 201800, China; 2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy Sciences, Changchun 130022, China

Received:2005-02-21 Online:2006-02-10 Published:2006-02-10
Contact: CHEN Xue-Si, xschen@ciac.jl.cn; YIN Jing-Bo，jbyin@staff.shu.edu.cn

摘要/Abstract

摘要：

采用三乙胺为催化剂经过氨基酸羧酸酐单体的开环聚合和脱保护基, 制备了高分子量聚L-谷氨酸. 实验结果表明, 合成的高分子量聚L-谷氨酸黏均分子量控制在70 000~350 000左右. 单体和引发剂的摩尔比n(A)/n(I)大于50时，分子量与n(A)/n(I)无关.

关键词: L-谷氨酸; L-谷氨酸苄酯; 聚-L-谷氨酸苄酯; 聚-L-谷氨酸

Abstract:

Abstract Poly-L-glutamic acid with a high molecular weight was prepared by chemical synthesis. The structures of PBLG and PLGA were confirmed by FTIR and 1H NMR spectroscopies and their molecular weights were measured by GPC and viscosity measurements. The results show that the average molecular weight of poly-L-glutamic acid is about 7×104\_35×104. Furthermore, when the anhydride-initiator malar ratio n(A)/n(I)>50, the average molecular weight was independent of the amount of triethylamine initiator.

Key words: Keywords L-Glutamic acid; γ-Benzyl L-glutamate; Poly(γ-benzyl L-glutamate); Poly-L-glutamic acid

中图分类号:

O631

TrendMD:

曹田尹静波罗坤陈红丹陈学思. 高分子量的聚L-谷氨酸的合成与表征. 高等学校化学学报, 2006, 27(2): 369.

CAO Tian, YIN Jing-Bo, LUO Kun, CHEN Hong-Dan, CHEN Xue-Si. Synthesis and Characterization of Poly-L-glutamic Acid with a High Molecular Weight. Chem. J. Chinese Universities, 2006, 27(2): 369.