高等学校化学学报

高等学校化学学报

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原位聚合法制备温敏性聚合物核壳胶束的响应温度调控及其负载行为

任现文, 江明
   

  1. 复旦大学高分子科学系, 教育部聚合物分子工程重点实验室, 上海 200433
  • 收稿日期:2006-04-06 修回日期:1900-01-01 出版日期:2006-11-10 发布日期:2006-11-10
  • 通讯作者: 江明

Adjustment of Responsive Temperature and Loading Behavior of Temperature-sensitive Core-shell Micelles Prepared via in-situ Polymerization

REN Xian-Wen, JIANG Ming   

  1. The Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Fudan University, Shanghai 200433, China
  • Received:2006-04-06 Revised:1900-01-01 Online:2006-11-10 Published:2006-11-10
  • Contact: JIANG Ming

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被引次数

31

摘要： 采用原位聚合法成功地制备出聚乳酸/聚(异丙基丙烯酰胺-co-丙烯酰胺)[P(D,L-LA)/PNIPAM-co-AM)\]温敏性核壳胶束. 用SEM, TEM和AFM等方法表征了粒子的外在形貌和内部结构. DLS研究结果表明, 所得核壳粒子的尺寸具有温度敏感性, 通过改变单体的投料比, 可方便地调整胶束粒子的响应温度. 对胶束粒子的染料负载行为做了初步的研究.

关键词: 核壳结构, 高分子胶束, 聚异丙基丙烯酰胺, 大分子自组装

Abstract: In-situ polymerization, which had been developed in our group, was employed to prepare thermo\|sensitive poly(D,L-lactic acid)/poly(N-isopropyl acrylamide-co-acrylamide)(PLA/PNIPAM-co-AM)core-shell micelles. The resultant micelles N100, N90 and N80 were obtained in which the mass fractions of hydrophilic AM units in the feeds were 0, 10% and 20%, respectively. SEM, TEM and AFM were used to observe the morphologies of the micelles and the results confirmed the core-shell structure. The nanoparticles show a significant size change with the variation of temperature. The diameter of N100 decreases from 207.3 nm to 140.1 nm when temperature increases from 27 ℃ to 41 ℃. The responsive temperatures of N100, N90 and N80 were found to be 33, 41 and 56 ℃, respectively, which means that the responsive temperature of the micelles can be adjusted by changing the shell compositions. In addition, the dye-loading behavior of the nanoparticles was also studied.

Key words: Core-shell structure, Polymeric micelle, Poly(N-isopropyl acrylamide), Macromolecular self-assembly

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